Jiang Xiaoming, Lu Yongyu, Hu Xiaogang, She Xiaochun
Department of Neurosurgery, Rudong Hospital Affiliated to Nantong University, Nantong, China.
Department of Neurosurgery, Haimen District People's Hospital, Nantong, China.
Front Neurol. 2022 Feb 18;13:729727. doi: 10.3389/fneur.2022.729727. eCollection 2022.
To explore the dissolution effect of alteplase (rt-PA) on arterial blood clots of patients with hypertensive cerebral hemorrhage and analyze the optimal concentration and action time of rt-PA for intracranial hematomas.
The arterial blood of 35 patients with confirmed hypertensive cerebral hemorrhage were collected, centrifuged, and the serum was aspirated to prepare the blood clot model. The 0.125, 0.25, 0.5, 1, 2, and 3 mg t-PA, 20,000 U, and 40,000 U urokinase (u-PA) were taken for the corresponding blood clot for dissolution test. The blood clot volume and dissolution volume was measured at 0, 30, 60, 90, 120, and 150 min.
Without intervention, the blood clot volume of men was higher than that of women at 0, 30, 60, and 90 min ( < 0.05). Without intervention, hematocrit (HCT) was correlated with blood clot volume and the correlation decreased with time. The 30, 60, and 90 min dissolution curves of each group showed an upward trend ( < 0.05), and the dissolution curves tended to be flat at 120 min and 150 min. The dissolution volume of.125 mg/3 ml, 0.25 mg/3 ml, 0.5 mg/3 ml rt-PA, 20,000 U, 40,000 U u-PA was higher than that of 1, 2, 3 mg/ml rt-PA ( < 0.05). The dissolution volume of.125 mg/3 ml, 0.25 mg/3 ml, 0.5 mg/3 ml rt-PA was not significantly different from 20,000 and 40,000 U u-PA ( > 0.05). Gender differences did not affect the effects of the above drugs.
, low-concentration rt-PA has a better dissolution effect, and it shows a time-dependent effect, reaching the highest effect in 90 min.
探讨阿替普酶（rt-PA）对高血压脑出血患者动脉血栓的溶解作用，分析rt-PA对颅内血肿的最佳浓度及作用时间。
收集35例确诊为高血压脑出血患者的动脉血，离心后吸取血清制备血栓模型。分别取0.125、0.25、0.5、1、2和3mg t-PA、20000U及40000U尿激酶（u-PA）对相应血栓进行溶解试验。于0、30、60、90、120和150分钟测量血栓体积及溶解体积。
未干预时，男性在0、30、60和90分钟时的血栓体积高于女性（P<0.05）。未干预时，血细胞比容（HCT）与血栓体积相关，且相关性随时间降低。各组30、60和90分钟的溶解曲线呈上升趋势（P<0.05），120分钟和150分钟时溶解曲线趋于平缓。0.125mg/3ml、0.25mg/3ml、0.5mg/3ml rt-PA、20000U、40000U u-PA的溶解体积高于1、2、3mg/ml rt-PA（P<0.05）。0.125mg/3ml、0.25mg/3ml、0.5mg/3ml rt-PA的溶解体积与20000和40000U u-PA无显著差异（P>0.05）。性别差异不影响上述药物的作用效果。
低浓度rt-PA具有较好的溶解效果，且呈时间依赖性，90分钟时达到最高效果。
