Else Kröner-Fresenius Center for Nutritional Medicine (EKFZ), Technical University of Munich, Freising, Germany.
Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
Front Endocrinol (Lausanne). 2022 Feb 17;13:849877. doi: 10.3389/fendo.2022.849877. eCollection 2022.
During the first month of postnatal life, adipose tissue depots of mice go through a drastic, but transient, remodeling process. Between postnatal days 10 and 20, several white fat depots display a strong and sudden surge in beige adipocyte emergence that reverts until day 30. At the same time, brown fat depots appear to undergo an opposite phenomenon. We comprehensively describe these events, their depot specificity and known environmental and genetic interactions, such as maternal diet, housing temperature and mouse strain. We further discuss potential mechanisms and plausible purposes, including the tempting hypothesis that postnatal transient remodeling creates a lasting adaptive capacity still detectable in adult animals. Finally, we propose postnatal adipose tissue remodeling as a model process to investigate mechanisms of beige adipocyte recruitment advantageous to cold exposure or adrenergic stimulation in its entirely endogenous sequence of events without external manipulation.
在产后生命的第一个月，小鼠的脂肪组织库经历了一个剧烈但短暂的重塑过程。在出生后第 10 天至第 20 天之间，几个白色脂肪库显示出米色脂肪细胞出现的强烈而突然的激增，这种现象一直持续到第 30 天。与此同时，棕色脂肪库似乎出现了相反的现象。我们全面描述了这些事件、它们的库特异性以及已知的环境和遗传相互作用，如母体饮食、居住温度和小鼠品系。我们进一步讨论了潜在的机制和合理的目的，包括一个诱人的假设，即产后短暂重塑为成年动物仍能检测到的持久适应性能力创造了条件。最后，我们提出产后脂肪组织重塑作为一个模型过程，以研究在完全内源性事件序列中，米色脂肪细胞募集的有利冷暴露或肾上腺素刺激的机制，而无需外部操作。
