Xia Feng, Ndhlovu Elijah, Zhang Mingyu, Chen Xiaoping, Zhang Bixiang, Zhu Peng
Department of Hepatic Surgery Center, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Department of Digestive Medicine. Tongji Hospital of Tongji Medical College in Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2022 Feb 17;12:848903. doi: 10.3389/fonc.2022.848903. eCollection 2022.
Ruptured hepatocellular carcinoma (rHCC) is considered a rare and life-threatening manifestation; when it happens, it often requires acute and positive intervention. At present, the mechanism of rHCC development is gradually being understood while there are many kinds of rHCC treatment. From our clinical observation, the prognosis of rHCC patients is not as poor as it is currently believed. It may not be appropriate to include all patients with rHCC in T4.
The incidence of ruptured hepatocellular carcinoma is now rising. Especially in the Asian region, it can even reach 10% - 15%. The most common symptom of HCC rupture is abdominal pain, and there are now a variety of treatments for hepatocellular carcinoma rupture. With aggressive treatment, rHCC patients can also achieve a better prognosis. The patient's condition varies on admission, so the treatment methods will also be different. It is critical to identify prognostic factors simultaneously, and rHCC can be effectively managed by focusing on important prognostic factors.
A review was carried out to analyze diagnosis, mechanism, treatment, and prognostic risk factors on this disease condition during the current situation; it is hoped that it will provide better guidance for clinicians. Moreover, patients with rHCC were managed hierarchically to prolong their prognosis.
破裂性肝细胞癌(rHCC)被认为是一种罕见且危及生命的表现;当其发生时,通常需要积极的干预措施。目前,rHCC的发病机制正逐渐被了解,同时rHCC有多种治疗方法。从我们的临床观察来看,rHCC患者的预后并不像目前认为的那么差。将所有rHCC患者都归为T4期可能并不合适。
破裂性肝细胞癌的发病率目前正在上升。尤其是在亚洲地区,其发病率甚至可达10% - 15%。HCC破裂最常见的症状是腹痛,目前针对肝细胞癌破裂有多种治疗方法。通过积极治疗,rHCC患者也可获得较好的预后。患者入院时病情各异,因此治疗方法也会不同。同时识别预后因素至关重要,通过关注重要的预后因素可以有效管理rHCC。
针对当前形势下该疾病的诊断、机制、治疗及预后危险因素进行了综述分析;希望能为临床医生提供更好的指导。此外,对rHCC患者进行分层管理以延长其预后。