Hatton G I
Fed Proc. 1986 Aug;45(9):2328-33.
Over the past decade or so, plasticity has emerged as an important, quantifiable property of the mammalian hypothalamic magnocellular neurosecretory system. This plasticity has turned out to be genuinely related to normal function in the sense that it is a set of responses to physiological stimulation rather than only the sequelae of insult or injury, and it is generally completely reversible. This latter property, of course, distinguishes it further from the plasticity observed after injury. Four features of this magnocellular system that have been shown to display predictable and reversible intercellular plasticity are reviewed: the relationships between neurons and their associated astrocytic glia at various levels (dendritic somatic and terminal) of the magnocellular elements; the extent of terminal and glial contact with the basement lamina in the neurohypophysis; the type and possible efficacy of synaptic input, and the extent of electrotonic coupling among the magnocellular neurons.
在过去十年左右的时间里，可塑性已成为哺乳动物下丘脑大细胞神经分泌系统的一种重要的、可量化的特性。这种可塑性已被证明与正常功能真正相关，因为它是对生理刺激的一组反应，而不仅仅是损伤或伤害的后遗症，并且通常是完全可逆的。当然，后一种特性使其与损伤后观察到的可塑性进一步区分开来。本文综述了该大细胞系统已被证明具有可预测和可逆的细胞间可塑性的四个特征：大细胞元件不同水平（树突体和终末）的神经元与其相关星形胶质细胞之间的关系；神经垂体中终末和胶质细胞与基膜的接触程度；突触输入的类型和可能的效能，以及大细胞神经元之间电紧张性耦合的程度。
