Kainuma Atsushi, Itatani Keiichi, Akiyama Koichi, Naito Yoshifumi, Ishii Maki, Shimizu Masaru, Ohara Junya, Nakamura Naotoshi, Nakajima Yasufumi, Numata Satoshi, Yaku Hitoshi, Sawa Teiji
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Front Surg. 2022 Feb 14;9:739743. doi: 10.3389/fsurg.2022.739743. eCollection 2022.
There is currently no subjective, definitive evaluation method for therapeutic indication other than symptoms in aortic regurgitation. Energy loss, a novel parameter of cardiac workload, can be visualized and quantified using echocardiography vector flow mapping. The purpose of the present study was to evaluate whether energy loss in patients with chronic aortic regurgitation can quantify their subjective symptoms more clearly than other conventional metrics.
We studied 15 patients undergoing elective aortic valve surgery for aortic regurgitation. We divided the patients into symptomatic and asymptomatic groups using their admission records. We analyzed the mean energy loss in one cardiac cycle using transesophageal echocardiography during the preoperative period. The relationships between symptoms, energy loss, and other conventional metrics were statistically analyzed.
There were seven and eight patients in the symptomatic and asymptomatic groups, respectively. The mean energy loss of one cardiac cycle was higher in the symptomatic group (121 mW/m [96-184]) than in the asymptomatic group (87 mW/m [80-103]) ( = 0.040), whereas the diastolic diameter was higher in the asymptomatic group (65 mm [59-78]) than in the symptomatic group (57 mm [51-57]) ( = 0.040). There was no significant difference between the symptomatic and asymptomatic groups in terms of other conventional metrics.
An energy loss can quantify patients' subjective symptoms more clearly than other conventional metrics. The small sample size is the primary limitation of our study, further studies assessing larger cohort of patients are warranted to validate our findings.
目前,除症状外,尚无用于评估主动脉瓣反流治疗指征的主观、明确的评估方法。能量损失作为心脏工作负荷的一个新参数,可通过超声心动图向量血流图进行可视化和量化。本研究的目的是评估慢性主动脉瓣反流患者的能量损失是否比其他传统指标能更清晰地量化其主观症状。
我们研究了15例因主动脉瓣反流接受择期主动脉瓣手术的患者。根据入院记录将患者分为有症状组和无症状组。在术前使用经食管超声心动图分析一个心动周期中的平均能量损失。对症状、能量损失和其他传统指标之间的关系进行统计学分析。
有症状组和无症状组分别有7例和8例患者。有症状组一个心动周期的平均能量损失(121 mW/m [96 - 184])高于无症状组(87 mW/m [80 - 103])(P = 0.040),而无症状组的舒张期直径(65 mm [59 - 78])高于有症状组(57 mm [51 - 57])(P = 0.040)。在其他传统指标方面,有症状组和无症状组之间无显著差异。
与其他传统指标相比,能量损失能更清晰地量化患者的主观症状。本研究的主要局限性是样本量小,有必要进一步开展研究评估更大规模的患者队列以验证我们的发现。