G Ital Cardiol. 1986 Mar;16(3):196-202.
The study has been conducted in 6027 men aged 40-59 at entry, for a total of 3131 treated and 2896 controls, distributed in two pairs of occupational groups. The preventive intervention included actions against some classical coronary risk factor i.e. diet and exceptionally drugs on cholesterol, anti-hypertensive drugs in hypertensives, anti-smoking advice in smokers, diet and increase of leisure physical activity in men with overweight. The treatment has lasted 6 years and has been accompanied by a significant reduction of the estimated multivariate coronary risk in treatment groups reaching a peak after 4 years (-26.5%) and a final value of -20.5% after 6 years. Coronary mortality in 10 years (the last 4 without treatment and risk factors measurements) has shown a maximum difference between treated and controls after 6 years (-29.5%) whereas at the end of 10 years it was of -23.5% (p less than 0.1). The final rates of coronary mortality were 34.1 per 1000 in controls and 26.1 per 1000 in treated men (benefit 8 per 1000). All causes mortality after 10 years was 94.8 per 1000 in controls and 89.1 per 1000 in treated groups with a benefit of 5.7 per 1000.
该研究纳入了6027名年龄在40 - 59岁的男性，其中3131人为治疗组，2896人为对照组，分为两对职业组。预防性干预措施包括针对一些典型的冠心病危险因素采取行动，即饮食干预，对胆固醇异常者使用药物治疗，对高血压患者使用抗高血压药物，对吸烟者提供戒烟建议，对超重男性进行饮食调整并增加休闲体育活动。治疗持续了6年，治疗组的估计多因素冠心病风险显著降低，在4年后达到峰值（-26.5%），6年后最终值为-20.5%。10年的冠心病死亡率（最后4年未进行治疗及危险因素测量）显示，6年后治疗组与对照组之间的差异最大（-29.5%），而在10年末差异为-23.5%（p小于0.1）。冠心病死亡率的最终比率在对照组为每1000人中有34.1人，在治疗组男性中为每1000人中有26.1人（每1000人受益8人）。10年后所有原因导致的死亡率在对照组为每1000人中有94.8人，在治疗组为每1000人中有89.1人，每1000人受益5.7人。
