Zhang Suojian, Li Haitao, Cai Xiaoqin, Zhao Caixia, Cao Juan
Department of Nephrology, Taixing People's Hospital, Taizhou, Jiangsu, China.
Ther Apher Dial. 2022 Dec;26(6):1241-1246. doi: 10.1111/1744-9987.13832. Epub 2022 Mar 14.
This study evaluated the association between serum cystatin C and residual renal function (RRF) in peritoneal dialysis (PD) patients.
The ability of cystatin C to predict RRF was assessed. Multivariate linear regression analysis was conducted to measure the impact of particular factors on serum cystatin C levels.
The study included 141 PD patients. Serum creatinine and cystatin C were negatively correlated with RRF (p < 0.05). Receiver operating characteristic (ROC) curves showed that serum creatinine and cystatin C could both predict RRF status (p < 0.05), but serum cystatin C had a larger area AUC than creatinine (0.893 vs. 0.757, respectively), p < 0.001). Multiple linear regression analysis revealed that RRF Kt/V and Ccr were independent factors affecting serum cystatin C levels (p < 0.001).
Serum cystatin C levels were closely associated with RRF in PD patients and could reliably predict RRF status. Serum cystatin C levels were determined by RRF, not by PD.
本研究评估了腹膜透析（PD）患者血清胱抑素C与残余肾功能（RRF）之间的关联。
评估了胱抑素C预测RRF的能力。进行多变量线性回归分析以测量特定因素对血清胱抑素C水平的影响。
该研究纳入了141例PD患者。血清肌酐和胱抑素C与RRF呈负相关（p < 0.05）。受试者工作特征（ROC）曲线显示，血清肌酐和胱抑素C均可预测RRF状态（p < 0.05），但血清胱抑素C的曲线下面积（AUC）大于肌酐（分别为0.893和0.757），p < 0.001）。多元线性回归分析显示，RRF的Kt/V和肌酐清除率（Ccr）是影响血清胱抑素C水平的独立因素（p < 0.001）。
PD患者血清胱抑素C水平与RRF密切相关，可可靠地预测RRF状态。血清胱抑素C水平由RRF决定，而非由腹膜透析决定。
