Bailey C J, Day C, Bray G A, Lipson L G, Flatt P R
Horm Metab Res. 1986 Jun;18(6):357-60. doi: 10.1055/s-2007-1012316.
This study evaluates the role of adrenal hormones in the development of hyperinsulinaemia and impaired glucose homeostasis in genetically obese hyperglycaemic C57BL/6J ob/ob mice. Lean (+/?) and obese mice were bilaterally adrenalectomised or sham operated at 5 weeks of age, and glucose tolerance was examined after 7 and 14 days. Adrenalectomy temporarily reduced food intake and body weight gain in lean mice, and improved glucose tolerance without a significant change in plasma insulin concentrations at both intervals studied. In obese mice adrenalectomy permanently reduced body weight gain and food intake to values comparable with lean mice. Glucose tolerance was improved in adrenalectomised obese mice at both intervals studied, resulting in plasma glucose concentrations similar to adrenalectomised lean mice. Plasma insulin concentrations during the tolerance tests were reduced in adrenalectomised obese mice, but remained higher than in lean mice. Adrenalectomy did not improve the poor insulin response to parenteral glucose in obese mice. The results indicate that adrenal hormones play an important role in the development of glucose intolerance and contribute to the hyperinsulinaemia in obese (ob/ob) mice, in part by promoting hyperphagia.
本研究评估了肾上腺激素在遗传性肥胖高血糖C57BL/6J ob/ob小鼠高胰岛素血症和葡萄糖稳态受损发展过程中的作用。将瘦型（+/？）和肥胖小鼠在5周龄时进行双侧肾上腺切除术或假手术，并在7天和14天后检测葡萄糖耐量。肾上腺切除术暂时降低了瘦型小鼠的食物摄入量和体重增加，并改善了葡萄糖耐量，在两个研究时间段血浆胰岛素浓度均无显著变化。在肥胖小鼠中，肾上腺切除术永久性地降低了体重增加和食物摄入量，使其达到与瘦型小鼠相当的值。在两个研究时间段，肾上腺切除的肥胖小鼠的葡萄糖耐量均得到改善，导致血浆葡萄糖浓度与肾上腺切除的瘦型小鼠相似。在葡萄糖耐量试验期间，肾上腺切除的肥胖小鼠的血浆胰岛素浓度降低，但仍高于瘦型小鼠。肾上腺切除术并未改善肥胖小鼠对胃肠外给予葡萄糖的不良胰岛素反应。结果表明，肾上腺激素在葡萄糖不耐受的发展中起重要作用，并且部分通过促进食欲亢进导致肥胖（ob/ob）小鼠出现高胰岛素血症。
