Freedman M R, Stern J S, Reaven G M, Mondon C E
Horm Metab Res. 1986 May;18(5):296-8. doi: 10.1055/s-2007-1012300.
Lean (Fa/?) and obese (fa/fa) Zucker rats were adrenalectomized (ADX) in order to assess the contribution of adrenal hormones to insulin resistance of the obese Zucker rat. Glucose utilization was measured using an insulin suppression test. Sham-operated obese rats gained almost twice as much weight as sham-operated lean littermates. However, body weight gain of ADX animals was comparable in both genotypes. It was significantly less than that of the respective sham-operated controls. Body weight differences can be accounted for almost entirely by a marked loss of adipose tissue. Although insulin resistance may be attributable to obesity in part, steroid hormones are thought to be directly antagonistic to insulin for glucose metabolism. Adrenalectomy resulted in a decrease in serum glucose concentrations for both lean and obese Zucker rats compared with their respective sham-operated groups. Serum insulin concentration of lean ADX rats was 23% of sham-operated controls; in obese ADX rats, it was 9% of controls. Elevated levels of steady state serum glucose (SSSG) levels in sham-operated obese rats demonstrate a marked resistance to insulin induced glucose uptake compared with sham-operated lean animals. Adrenalectomy caused a marked improvement in insulin sensitivity of obese rats. The hyperglycemic SSSG levels of the obese rats were reduced 2.5 times by ADX. These results indicate that insulin resistance of Zucker obese rats can be ameliorated by ADX, suggesting adrenal hormones contribute to insulin resistance in these animals.
为了评估肾上腺激素对肥胖型 Zucker 大鼠胰岛素抵抗的影响，对瘦型（Fa/?）和肥胖型（fa/fa）Zucker 大鼠进行了肾上腺切除术（ADX）。使用胰岛素抑制试验测量葡萄糖利用率。假手术的肥胖大鼠体重增加几乎是假手术的瘦型同窝大鼠的两倍。然而，ADX 动物的体重增加在两种基因型中相当。它明显低于各自的假手术对照组。体重差异几乎完全可以由脂肪组织的显著减少来解释。虽然胰岛素抵抗可能部分归因于肥胖，但类固醇激素被认为在葡萄糖代谢方面直接拮抗胰岛素。与各自的假手术组相比，肾上腺切除术导致瘦型和肥胖型 Zucker 大鼠的血清葡萄糖浓度降低。瘦型 ADX 大鼠的血清胰岛素浓度是假手术对照组的 23%；在肥胖型 ADX 大鼠中，它是对照组的 9%。与假手术的瘦型动物相比，假手术的肥胖大鼠中稳态血清葡萄糖（SSSG）水平升高表明对胰岛素诱导的葡萄糖摄取有明显抵抗。肾上腺切除术使肥胖大鼠的胰岛素敏感性有显著改善。肥胖大鼠的高血糖 SSSG 水平通过 ADX 降低了 2.5 倍。这些结果表明，肾上腺切除术可以改善 Zucker 肥胖大鼠的胰岛素抵抗，提示肾上腺激素在这些动物中促成了胰岛素抵抗。
