Menestrina F, Chilosi M, Bonetti F, Lestani M, Scarpa A, Novelli P, Doglioni C, Todeschini G, Ambrosetti A, Fiore-Donati L
Histopathology. 1986 Jun;10(6):589-600. doi: 10.1111/j.1365-2559.1986.tb02512.x.
Eight cases of mediastinal non-lymphoblastic large-cell lymphoma have been studied by histopathological and immunohistochemical methods. A common clinical, morphological and immunophenotypic pattern was identified. Six of eight cases proved to be of B-cell origin by the expression of B-associated antigens detected by specific monoclonal antibodies. Cells of large size with nuclei of varying morphology and a peculiar type of fine compartmentalizing fibrosis were observed in all specimens. Clinically the disease was characterized by the young age of the patients, primary mediastinal involvement, aggressive behaviour and spread to unusual sites (kidneys in four cases). This seems to be a hitherto unrecognized entity in the field of non-Hodgkin's lymphomas, often misdiagnosed because of location and a morphology uncommon for B-cell malignancies. Immunohistochemical analysis on frozen tissue sections appears to be mandatory for a correct diagnosis. Nevertheless, this type of lymphoma could be suspected also on the basis of its peculiar clinicopathological characteristics.
通过组织病理学和免疫组织化学方法对8例纵隔非淋巴细胞性大细胞淋巴瘤进行了研究。确定了一种常见的临床、形态学和免疫表型模式。通过特异性单克隆抗体检测到的B相关抗原的表达，8例中有6例被证明为B细胞起源。在所有标本中均观察到细胞核形态各异的大细胞以及一种特殊类型的细微分隔性纤维化。临床上，该疾病的特征为患者年龄较轻、原发性纵隔受累、侵袭性病程以及扩散至不常见部位（4例累及肾脏）。这似乎是一种非霍奇金淋巴瘤领域中迄今未被认识的实体，常常因位置和B细胞恶性肿瘤不常见的形态而被误诊。对冰冻组织切片进行免疫组织化学分析对于正确诊断似乎是必不可少的。然而，基于其特殊的临床病理特征，也可怀疑为此类淋巴瘤。
