Clin Lab. 2022 Mar 1;68(3). doi: 10.7754/Clin.Lab.2021.210726.
Excessive systemic inflammation plays a vital role in pathophysiology of preeclampsia (PE). The aim is to clarify the predictive value of the peripheral blood parameters including white blood cell (WBC), neutrophils, lymphocyte, monocyte, platelet count, mean platelet volume (MPV), plateletcrit, platelet distribution width (PDW), platelet-large cell ratio (PLCR), and the ratio value for PE.
This retrospective study enrolled 170 PE patients, 123 healthy control pregnant women, and 122 non-pregnant women. When pregnant women were admitted to the hospital for delivery, peripheral complete blood cell count was detected by an automatic blood cell analyzer. Clinical signs and demographic characteristics were recorded. The receiver operating characteristic (ROC) curve was used to determine the cutoff value and analyze the predictive significances for PE. Furthermore, the risk factors of PE were tested by univariate and stratified analyses.
This study showed that WBC, neutrophil count, neutrophil percentage, NLR, NMR, and PLR# were significantly increased in PE patients as compared with pregnant control patients (p < 0.001), whereas lymphocyte percentage, monocyte percentage, and PNR were decreased. In addition, there was no significant difference in the rest of the peripheral blood parameters between women with and without PE. The ROC curve result revealed that WBC and neutrophil count had a higher AUC value than the rest of peripheral blood variables. WBC and neutrophil count are positively correlated MAP. Moreover, the WBC and neutrophil count were indicated as independent risk factors for the development of PE.
This study clarifies that peripheral blood parameters of WBC and neutrophil count have good applied value with high sensitivity and specificity in predicting the development of PE and are also independent risk factors for the development of PE.
过度的全身炎症在子痫前期（PE）的病理生理学中起着至关重要的作用。目的是阐明包括白细胞（WBC）、中性粒细胞、淋巴细胞、单核细胞、血小板计数、血小板平均体积（MPV）、血小板比容、血小板分布宽度（PDW）、血小板大细胞比（PLCR）和比值在内的外周血参数对 PE 的预测价值。
本回顾性研究纳入了 170 例 PE 患者、123 例健康妊娠对照孕妇和 122 名非妊娠妇女。当孕妇因分娩住院时，通过自动血细胞分析仪检测外周全血细胞计数。记录临床体征和人口统计学特征。使用受试者工作特征（ROC）曲线确定截断值，并分析其对 PE 的预测意义。此外，通过单因素和分层分析检测 PE 的危险因素。
本研究表明，与妊娠对照孕妇相比，PE 患者的 WBC、中性粒细胞计数、中性粒细胞百分比、NLR、NMR 和 PLR#显著增加（p<0.001），而淋巴细胞百分比、单核细胞百分比和 PNR 降低。此外，患有 PE 的女性与不患有 PE 的女性之间的其余外周血参数没有差异。ROC 曲线结果表明，WBC 和中性粒细胞计数的 AUC 值高于其余外周血变量。WBC 和中性粒细胞计数与 MAP 呈正相关。此外，WBC 和中性粒细胞计数被认为是 PE 发展的独立危险因素。
本研究表明，WBC 和中性粒细胞计数等外周血参数对预测 PE 的发生具有良好的应用价值，其灵敏度和特异性均较高，并且是 PE 发生的独立危险因素。
