Pandhi P, Sharma P L, Sharma B K, Wahi P L
Int J Clin Pharmacol Ther Toxicol. 1986 May;24(5):249-53.
The effect of propranolol and labetalol on cold stress and isometric exercise induced rise of blood pressure was studied in 7 patients with essential hypertension and 14 normal volunteers in a controlled, double blind, randomized, cross-over trial design. The subjects received either propranolol (40 mg) or labetalol (100 mg) orally after breakfast. In patients of mild to moderate essential hypertension, labetalol reduced significantly both systolic as well as diastolic rise of blood pressure induced by both types of exercises. Propranolol only reduced the rise of systolic blood pressure significantly. In normotensive subjects, labetalol reduced significantly the rise in systolic as well as diastolic blood pressure induced by cold stress, but not by the isometric exercise, while propranolol only reduced significantly the rise in systolic blood pressure induced by both the tests. The rise in heart rate was more with isometric exercise than with cold stress both in hypertensive patients and control subjects. The heart rate rise was significantly reduced by propranolol in all the experiments except for the rise induced by cold stress in hypertensive patients. The changes in heart rate produced by labetalol were not significant.
在一项对照、双盲、随机、交叉试验设计中，对7例原发性高血压患者和14名正常志愿者研究了普萘洛尔和拉贝洛尔对冷应激及等长运动诱发的血压升高的影响。受试者在早餐后口服普萘洛尔（40毫克）或拉贝洛尔（100毫克）。在轻度至中度原发性高血压患者中，拉贝洛尔可显著降低两种运动诱发的收缩压和舒张压升高。普萘洛尔仅显著降低收缩压升高。在血压正常的受试者中，拉贝洛尔可显著降低冷应激诱发的收缩压和舒张压升高，但对等长运动诱发的血压升高无影响，而普萘洛尔仅显著降低两种试验诱发的收缩压升高。在高血压患者和对照受试者中，等长运动引起的心率升高均高于冷应激引起的心率升高。除高血压患者冷应激诱发的心率升高外，普萘洛尔在所有实验中均显著降低心率升高。拉贝洛尔引起的心率变化不显著。
