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法国全国登记注册队列研究:家庭透析应用中透析网络的变异性无法用患者特征解释。

Dialysis-network variability in home dialysis use not explained by patient characteristics: a national registry-based cohort study in France.

机构信息

REIN registry, Agence de la biomédecine, Saint-Denis La Plaine, France.

Université Lyon I, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique Santé, VilleurbanneFrance.

出版信息

Nephrol Dial Transplant. 2022 Sep 22;37(10):1962-1973. doi: 10.1093/ndt/gfac055.

Abstract

BACKGROUND

Although associated with better quality of life and potential economic advantages, home dialysis use varies greatly internationally and appears to be underused in many countries. This study aimed to estimate the dialysis-network variability in home dialysis use and identify factors associated with (i) the uptake in home dialysis, (ii) the proportion of time spent on home dialysis and (iii) home dialysis survival (patient and technique).

METHODS

All adults ≥18 years old who had dialysis treatment during 2017-2019 in mainland France were included. Mixed-effects regression models were built to explore factors including patient or residence characteristics and dialysis network associated with variation in home dialysis use.

RESULTS

During 2017-2019, 7728/78 757 (9.8%) patients underwent dialysis at least once at home for a total of 120 594/1 508 000 (8%) months. The heterogeneity at the dialysis-network level and to a lesser extent the regional level regarding home dialysis uptake or total time spent was marginally explained by patient characteristics or residence and dialysis-network factors. Between-network heterogeneity was less for patient and technique survival. These results were similar when the analysis was restricted to home peritoneal dialysis or home hemodialysis.

CONCLUSIONS

Variability between networks in the use of home dialysis was not fully explained by non-modifiable patient and residence characteristics. Our results suggest that to increase home dialysis use in France, one should focus on home dialysis uptake rather than survival. Financial incentives and a quality improvement programme should be implemented at the dialysis-network level to increase home dialysis use.

摘要

背景

尽管居家透析与更好的生活质量和潜在的经济优势相关,但国际上居家透析的使用差异很大,而且在许多国家似乎未得到充分利用。本研究旨在评估透析网络中居家透析使用的变异性,并确定与以下因素相关的因素:(i)居家透析的采用率,(ii)居家透析时间的比例,以及(iii)居家透析的患者和技术生存率。

方法

本研究纳入了 2017-2019 年期间在法国本土接受透析治疗的所有≥18 岁的成年人。使用混合效应回归模型来探索与居家透析使用变化相关的患者或居住地特征以及透析网络因素。

结果

在 2017-2019 年期间,7728/78757(9.8%)名患者至少在家中进行了一次透析,共进行了 120594/1508000(8%)个月的居家透析。透析网络之间以及在较小程度上的区域之间在居家透析采用率或总透析时间方面的异质性仅部分由患者特征或居住地和透析网络因素来解释。患者和技术生存率的网络间异质性较小。当分析仅限于家庭腹膜透析或家庭血液透析时,结果相似。

结论

居家透析使用的网络间变异性不能完全由不可改变的患者和居住地特征来解释。我们的研究结果表明,为了增加法国的居家透析使用率,应重点提高居家透析的采用率,而不是提高生存率。应在透析网络层面实施经济激励和质量改进计划,以增加居家透析的使用。

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