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当位置信息不明确时，海马体非位置细胞的目标辨别。

Goal discrimination in hippocampal nonplace cells when place information is ambiguous.

机构信息

Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332.

Neuroscience Graduate Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322.

出版信息

Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2107337119. doi: 10.1073/pnas.2107337119. Epub 2022 Mar 7.

DOI:10.1073/pnas.2107337119
PMID:35254897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8931233/
Abstract

SignificanceGoal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that "nonplace" cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace cell activity is performance-dependent and is modulated by gamma oscillations. Finally, nonplace cell goal discrimination coding fails in a mouse model of Alzheimer's disease (AD). Together, these results show that nonplace cell firing can signal unique task-relevant information when spatial information is ambiguous; these signals depend on performance and are absent in a mouse model of AD.

摘要

意义

目标导向的空间导航被发现依赖于空间调制的海马神经元。我们表明，当目标的环境线索不明确时，没有显著空间调制的“非位置”细胞在区分目标方面发挥作用。这种非位置细胞活动是依赖于性能的，并受伽马振荡的调节。最后，在阿尔茨海默病（AD）的小鼠模型中，非位置细胞的目标判别编码失败。总之，这些结果表明，当空间信息不明确时，非位置细胞的放电可以发出与任务相关的独特信息；这些信号取决于性能，并且在 AD 的小鼠模型中不存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/4f817909ca92/pnas.2107337119fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/6f4107e3bcf5/pnas.2107337119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/cce280837bb0/pnas.2107337119fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/bed32ae82f21/pnas.2107337119fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/4f817909ca92/pnas.2107337119fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/6f4107e3bcf5/pnas.2107337119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/cce280837bb0/pnas.2107337119fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/bed32ae82f21/pnas.2107337119fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8125/8931233/4f817909ca92/pnas.2107337119fig04.jpg

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