路易体痴呆与心房颤动风险增加相关：一项病例对照研究。

Lewy body dementia is associated with an increased risk of atrial fibrillation: A case-control study.

作者信息

Tábuas-Pereira Miguel, Durães João, Beato-Coelho José, Rita Nogueira Ana, Duro Diana, Baldeiras Inês, Santana Isabel

机构信息

Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.

Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.

出版信息

J Clin Neurosci. 2022 May;99:62-65. doi: 10.1016/j.jocn.2022.02.038. Epub 2022 Mar 4.

DOI:10.1016/j.jocn.2022.02.038

PMID:35255358

Abstract

BACKGROUND

Lewy bodies are a hallmark of Dementia with Lewy Bodies. They can also be found in the sinoatrial node and may be associated with heart disease.

OBJECTIVES

We aimed to investigate a possible association between Lewy Body dementia and atrial fibrillation.

METHODS

We performed a case-control study based on our centre's cohort of degenerative dementia (Dementia with Lewy Bodies and Alzheimer's disease) patients. The possible association between Lewy Body dementia and atrial fibrillation was studied through a binomial logistic regression, which adjusted for comorbidity data.

RESULTS

We included 461 patients. 45 of the 398 (11.3%) with Alzheimer's disease and 14 of the 63 with Dementia with Lewy Bodies (22.2%) had atrial fibrillation. Heart failure (OR = 3.345, 95%CI = [1.618, 6.916], p = 0.001), hypertension (OR = 2.547, 95%CI = [1,137, 5.703], p = 0.023), stroke (OR = 2.274, 95%CI = [1.013, 5.103], p = 0.046) and Dementia with Lewy Bodies (OR = 2.536, 95%CI = [1.105, 5.822], p = 0.028) were associated with atrial fibrillation.

CONCLUSIONS

We found an association between Dementia with Lewy bodies and Atrial Fibrillation.

摘要

背景

路易小体是路易体痴呆的一个标志。它们也可在窦房结中发现，并且可能与心脏病有关。

目的

我们旨在研究路易体痴呆与心房颤动之间可能存在的关联。

方法

我们基于本中心的退行性痴呆（路易体痴呆和阿尔茨海默病）患者队列进行了一项病例对照研究。通过二项逻辑回归研究路易体痴呆与心房颤动之间可能存在的关联，并对合并症数据进行了调整。

结果

我们纳入了461名患者。398名阿尔茨海默病患者中有45名（11.3%）患有心房颤动，63名路易体痴呆患者中有14名（22.2%）患有心房颤动。心力衰竭（比值比[OR]=3.345，95%置信区间[CI]=[1.618, 6.916]，p=0.001）、高血压（OR=2.547，95%CI=[1.137, 5.703]，p=0.023）、中风（OR=2.274，95%CI=[1.013, 5.103]，p=0.046）和路易体痴呆（OR=2.536，95%CI=[1.105, 5.822]，p=0.028）与心房颤动有关。