University of Florida, Department of Epidemiology, 2004 Mowry Road, Gainesville, FL, 32610, USA.
University of Florida, Department of Psychiatry, 100 Newell Dr, Gainesville, FL, 32610, USA.
J Psychiatr Res. 2022 May;149:68-75. doi: 10.1016/j.jpsychires.2022.02.035. Epub 2022 Mar 2.
Hoarding disorder often results in debilitating functional impairment and may also compromise health-related quality of life (QoL). This study investigated the association between hoarding behavior and QoL relative to six highly impairing medical and psychiatric disorders in a sample of 20,722 participants enrolled in the internet-based Brain Health Registry. Nearly 1 in 8 participants (12.2%) endorsed clinically relevant hoarding symptoms (CHS). In separate multivariable linear regression models, hoarding was more strongly associated with mental QoL than diabetes (Standardizedβ = -0.21, 95% CI: [-0.22, -0.20] vs. -0.01 [-0.02, 0.0]), heart disease (-0.22 [-0.23, -0.20] vs. 0.00 [-0.02, 0.01]), chronic pain (-0.18 [-0.19, -0.16] vs. -0.12 [-0.13, -0.10]), post-traumatic stress disorder (PTSD; -0.20 [-0.22, -0.19] vs. -0.07 [-0.09, -0.06]), and substance use disorder (SUD; -0.21 [-0.23, -0.20] vs. -0.04 [-0.05, -0.03]). Similarly, CHS was more strongly negatively associated with physical QoL than diabetes (-0.11 [-0.10, -0.12] vs. -0.08 [-0.06, -0.09]), major depressive disorder (-0.09 [-0.10, -0.08] vs. -0.05 [-0.06, 0.03]), PTSD (-0.11 [-0.12, -0.10] vs. -0.08 [-0.09, -0.07]), and SUD (-0.12 [-0.13, -0.09] vs. -0.01 [-0.02, 0.00]). Higher hoarding severity was associated with reductions in both mental (Standardizedβ = -0.28, ΔR = 0.08, p < 0.0001) and physical (β = -0.12, ΔR = 0.02, p < 0.0001) QoL, though the strength of the relationship between hoarding symptoms and QoL varied with depression severity. Efforts to improve the overall QoL and well-being of those with CHS are needed.
囤积症常导致使人衰弱的功能障碍，也可能损害与健康相关的生活质量（QoL）。本研究在一个包含 20722 名参与者的互联网大脑健康登记处的样本中，调查了囤积行为与 6 种高度致残的医学和精神疾病的 QoL 之间的关联。近 1/8 的参与者（12.2%）表现出具有临床意义的囤积症状（CHS）。在单独的多变量线性回归模型中，囤积症与心理健康 QoL 的关联比糖尿病更密切（标准化β=-0.21，95%CI：[-0.22，-0.20] 比 -0.01[-0.02，0.0]），心脏病（-0.22[-0.23，-0.20] 比 0.00[-0.02，0.01]），慢性疼痛（-0.18[-0.19，-0.16] 比 -0.12[-0.13，-0.10]），创伤后应激障碍（PTSD；-0.20[-0.22，-0.19] 比 -0.07[-0.09，-0.06]）和物质使用障碍（SUD；-0.21[-0.23，-0.20] 比 -0.04[-0.05，-0.03]）。同样，CHS 与身体健康 QoL 的负相关性也比糖尿病更强（-0.11[-0.10，-0.12] 比 -0.08[-0.06，-0.09]），重度抑郁症（-0.09[-0.10，-0.08] 比 -0.05[-0.06，0.03]），PTSD（-0.11[-0.12，-0.10] 比 -0.08[-0.09，-0.07]）和 SUD（-0.12[-0.13，-0.09] 比 -0.01[-0.02，0.00]）。囤积症严重程度越高，与心理健康（标准化β=-0.28，ΔR=0.08，p<0.0001）和身体健康（β=-0.12，ΔR=0.02，p<0.0001）QoL 呈负相关，尽管囤积症状与 QoL 之间的关系强度随抑郁严重程度而变化。需要努力提高患有 CHS 的人的整体 QoL 和幸福感。
