Han Ae Ra, Lee Dayong, Kim Seul Ki, Choo Chang Woo, Park Joon Cheol, Lee Jung Ryeol, Choi Won Jun, Jun Jin Hyun, Rhee Jeong Ho, Kim Seok Hyun
Department of Obstetrics and Gynecology, CHA Fertility Center, CHA University School of Medicine, Daegu, Republic of Korea.
Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Clin Exp Reprod Med. 2022 Mar;49(1):2-8. doi: 10.5653/cerm.2022.05225. Epub 2022 Feb 28.
Humanity is in the midst of the coronavirus disease 2019 (COVID-19) pandemic, and vaccines-including mRNA vaccines-have been developed at an unprecedented speed. It is necessary to develop guidelines for vaccination for people undergoing treatment with assisted reproductive technology (ART) and for pregnancy-related situations based on the extant laboratory and clinical data. COVID-19 vaccines do not appear to adversely affect gametes, embryos, or implantation; therefore, active vaccination is recommended for women or men who are preparing for ART. The use of intravenous immunoglobulin G (IVIG) for the treatment of immune-related infertility is unlikely to impact the effectiveness of the vaccines, so COVID-19 vaccines can be administered around ART cycles in which IVIG is scheduled. Pregnant women have been proven to be at risk of severe maternal and neonatal complications from COVID-19. It does not appear that COVID-19 vaccines harm pregnant women or fetuses; instead, they have been observed to deliver antibodies against severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) to the fetus. Accordingly, it is recommended that pregnant women receive COVID-19 vaccination. There is no rationale for adverse effects, or clinical cases of adverse reactions, in mothers or neonates after COVID-19 vaccination in lactating women. Instead, antibodies to SARS-CoV-2 can be delivered through breast milk. Therefore, breastfeeding mothers should consider vaccination. In summary, active administration of COVID-19 vaccines will help ensure the safe implementation of ART, pregnancy, and breastfeeding.
人类正处于2019冠状病毒病（COVID-19）大流行之中，包括mRNA疫苗在内的疫苗以前所未有的速度研发出来。有必要根据现有的实验室和临床数据，为接受辅助生殖技术（ART）治疗的人群以及与妊娠相关的情况制定疫苗接种指南。COVID-19疫苗似乎不会对配子、胚胎或着床产生不利影响；因此，建议准备接受ART的女性或男性进行主动接种。使用静脉注射免疫球蛋白G（IVIG）治疗免疫相关不孕症不太可能影响疫苗的效力，所以在计划使用IVIG的ART周期前后可以接种COVID-19疫苗。已证实孕妇有感染COVID-19而出现严重孕产妇和新生儿并发症的风险。COVID-19疫苗似乎不会伤害孕妇或胎儿；相反，观察发现它们能将抗严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的抗体传递给胎儿。因此，建议孕妇接种COVID-19疫苗。哺乳期妇女接种COVID-19疫苗后，母亲或新生儿没有出现不良反应的理论依据或临床病例。相反，抗SARS-CoV-2抗体可以通过母乳传递。因此，哺乳期母亲应考虑接种疫苗。总之，主动接种COVID-19疫苗将有助于确保ART、妊娠和母乳喂养的安全实施。
