真菌天然产物生物合成中的分支和汇聚途径。
Branching and converging pathways in fungal natural product biosynthesis.
作者信息
Wei Xingxing, Wang Wei-Guang, Matsuda Yudai
机构信息
Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education and Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission, Yunnan Minzu University, Kunming, 650031, China.
出版信息
Fungal Biol Biotechnol. 2022 Mar 7;9(1):6. doi: 10.1186/s40694-022-00135-w.
In nature, organic molecules with great structural diversity and complexity are synthesized by utilizing a relatively small number of starting materials. A synthetic strategy adopted by nature is pathway branching, in which a common biosynthetic intermediate is transformed into different end products. A natural product can also be synthesized by the fusion of two or more precursors generated from separate metabolic pathways. This review article summarizes several representative branching and converging pathways in fungal natural product biosynthesis to illuminate how fungi are capable of synthesizing a diverse array of natural products.
在自然界中，利用相对少量的起始原料就能合成结构多样且复杂的有机分子。自然界采用的一种合成策略是途径分支，即一种常见的生物合成中间体转化为不同的终产物。天然产物也可以通过融合来自不同代谢途径产生的两种或更多种前体来合成。这篇综述文章总结了真菌天然产物生物合成中几种具有代表性的分支和汇聚途径，以阐明真菌如何能够合成各种各样的天然产物。
Zotero 插件