Sun Qiao, Xie Xiao, Song Yujie, Sun Litao
SEU-FEI Nano-Pico Center, Key Laboratory of MEMS of Ministry of Education, School of Electronic Engineering, Southeast University, Nanjing, 210096, China.
Center for Advanced Materials and Manufacture, Southeast University-Monash University Joint Research Institute, Suzhou, 215123, China.
Biomater Res. 2022 Mar 7;26(1):9. doi: 10.1186/s40824-022-00254-w.
The investigation of the interaction between metal ions and DNA has always attracted much attention in the fields of bioinorganic chemistry, supramolecular coordination chemistry, and DNA nanotechnology. Its mode of action can be simply divided into two aspects. On the one hand, it is non-specific electrostatic adsorption, mainly including Na, K, Mg, Ca and other physiologically regulating ions; on the other hand, it is specific covalent binding, such as Pt, Hg, Ag and other heavy metal ions. This article focuses on the mechanism of action between Ag and DNA mismatch pair C-C, and summarizes its main characterization methods and various applications. It aims to provide a certain reference for the field of biological devices. With the development of cryo-electron microscopy and liquidcell TEM, the structure of C-Ag-C is expected to be further characterized, which will be more widely used.
金属离子与DNA之间相互作用的研究在生物无机化学、超分子配位化学和DNA纳米技术领域一直备受关注。其作用方式可简单分为两个方面。一方面，是非特异性静电吸附，主要包括Na、K、Mg、Ca等生理调节离子；另一方面，是特异性共价结合，如Pt、Hg、Ag等重金属离子。本文重点关注Ag与DNA错配碱基对C-C之间的作用机制，并总结其主要表征方法及各种应用。旨在为生物器件领域提供一定参考。随着冷冻电子显微镜和液池透射电子显微镜的发展，C-Ag-C的结构有望得到进一步表征，其应用也将更加广泛。
