St George's University of London, London, SW17 0RE, UK; University of Nicosia Medical School, University of Nicosia, 2417, Nicosia, Cyprus.
St George's University of London, London, SW17 0RE, UK; University of Nicosia Medical School, University of Nicosia, 2417, Nicosia, Cyprus.
Am J Surg. 2022 Jul;224(1 Pt B):348-357. doi: 10.1016/j.amjsurg.2022.03.002. Epub 2022 Mar 3.
The aim of this meta-analysis was to assess the safety and efficacy of laparoscopic surgery when compared to open surgery in the management of gallbladder cancer.
Ovid Cochrane Library, Medline, Embase, Epub, and Scopus were searched. A meta-analysis of selected studies was performed, and a subgroup analysis was performed by tumor stage.
Fourteen studies met the eligibility criteria with a total of 1792 participants undergoing either laparoscopic or open surgery. Survival rate of laparoscopic group was higher than open group at T2 tumor stage after 1 year (OR = 2.130, 95%CI: 1.372, 3.306, I = 0%) and 2 year (OR = 2.074, 95%CI: 1.411, 3.050, I = 0%) as well as T3 tumor stage after 1 year (OR = 2.805, 95%CI: 1.631, 4.826, I = 0%) and 2 year (OR = 2.453, 95%CI: 1.367, 4.400, I = 0%). Additionally, overall recurrence rate between laparoscopic and open cohorts was similar (OR: 1.098, 95%CI: 0.774, 1.558, I = 5.56%).
In comparison to open surgery, the results seem to show a trend favoring laparoscopic surgery as a possible alternative treatment option to commence the management of gallbladder cancer.
本荟萃分析旨在评估腹腔镜手术与开放手术治疗胆囊癌的安全性和疗效。
检索了 Ovid Cochrane 图书馆、Medline、Embase、Epub 和 Scopus。对选定的研究进行了荟萃分析，并按肿瘤分期进行了亚组分析。
14 项研究符合入选标准，共有 1792 名患者接受了腹腔镜或开放手术。在 T2 肿瘤分期，腹腔镜组的 1 年（OR=2.130，95%CI：1.372，3.306，I=0%）和 2 年（OR=2.074，95%CI：1.411，3.050，I=0%）生存率均高于开放组；在 T3 肿瘤分期，腹腔镜组的 1 年（OR=2.805，95%CI：1.631，4.826，I=0%）和 2 年（OR=2.453，95%CI：1.367，4.400，I=0%）生存率也高于开放组。此外，腹腔镜组和开放组的总复发率相似（OR：1.098，95%CI：0.774，1.558，I=5.56%）。
与开放手术相比，结果似乎表明腹腔镜手术作为一种可能的替代治疗选择，可用于开始胆囊癌的治疗。
