Department of Pediatrics, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil;
Department of General Medicine, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Allergol Immunopathol (Madr). 2022 Mar 1;50(2):48-57. doi: 10.15586/aei.v50i2.539. eCollection 2022.
Better knowledge and understanding about drug desensitization is required in the pediatric population, since there is little literature available about it and the most pediatric desensitization protocols have been adapted from adult instructions.Aiming to soften this issue and foster the future studies, this article presents a recent review about mechanisms of desensitization, diagnostic tools, and up to date management of drug hypersensitivity reactions in children. Bringing up an overview of pediatric hypersensitivity reactions to chemotherapy, biologic agents, antibiotics, nonsteroidal anti-inflammatory drugs, and vaccines.
需要更好地了解儿科人群中的药物脱敏知识，因为关于这方面的文献很少，而且大多数儿科脱敏方案都是从成人指导中改编而来。为了缓解这一问题并促进未来的研究，本文对脱敏机制、诊断工具以及儿童药物过敏反应的最新管理进行了综述。本文还综述了儿科对化疗药物、生物制剂、抗生素、非甾体抗炎药和疫苗的过敏反应。
