School of Public Health.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, Suzhou, China.
Blood Press Monit. 2022 Aug 1;27(4):227-232. doi: 10.1097/MBP.0000000000000592. Epub 2022 Mar 7.
Studies on associations of erythrocytes parameters with hypertension risk are scarce. We aimed to examine associations of the erythrocytes parameters with the hypertension risk and potential effect modification by gender using data from the China Health and Nutrition Survey.
A total of 5419 eligible participants (2468 men, 45.5%) without hypertension at baseline in 2009 were included and followed for a median of 6.1 years. Parameters of erythrocytes and hemoglobin were measured at baseline. Multivariable Cox proportional hazards models were used to estimate the hazard ratio for the associations between these parameters and hypertension risk. Data were collected from 2009 to 2015 and analyzed in 2021.
A total of 1178 incident cases of hypertension were identified during the follow-up. In women, erythrocytes and hemoglobin were positively associated with risk of hypertension, yielding the highest hazard ratio in the third quartile of 1.59 (95% confidence interval, 1.28-1.97, P trend < 0.001) for erythrocytes and in the fourth quartile of 1.64 (95% confidence interval, 1.23-2.17, P trend < 0.001) for hemoglobin compared with their first quartile, respectively. In addition, quartiles of erythrocytes and hemoglobin were not associated with risk of hypertension in men ( P trend > 0.050).
Erythrocytes and hemoglobin were associated with an increased risk of hypertension in women, but not in men. Our findings suggest that special attention for the prevention of hypertension should be given to those women with the moderate to high level of circulating erythrocytes and higher level of hemoglobin.
关于红细胞参数与高血压风险之间关联的研究较少。我们旨在使用中国健康与营养调查的数据，检验红细胞参数与高血压风险之间的关联，并探讨性别是否对此有潜在的修饰作用。
共纳入了 5419 名 2009 年基线时无高血压且符合条件的参与者（男性 2468 名，占 45.5%），中位随访时间为 6.1 年。在基线时测量了红细胞和血红蛋白的参数。采用多变量 Cox 比例风险模型来估计这些参数与高血压风险之间的关联的风险比。数据收集于 2009 年至 2015 年，并于 2021 年进行分析。
在随访期间共确定了 1178 例高血压事件。在女性中，红细胞和血红蛋白与高血压风险呈正相关，在红细胞第三四分位数时最高风险比为 1.59（95%置信区间，1.28-1.97，P 趋势 <0.001），在血红蛋白第四四分位数时最高风险比为 1.64（95%置信区间，1.23-2.17，P 趋势 <0.001），与第一四分位数相比。此外，红细胞和血红蛋白四分位数与男性的高血压风险无关（P 趋势>0.050）。
红细胞和血红蛋白与女性高血压风险增加相关，但与男性无关。我们的研究结果表明，对于那些循环红细胞水平中等偏高和血红蛋白水平较高的女性，应特别注意预防高血压。
