高血脂与子痫前期风险。
Hyperlipidemia and risk for preclampsia.
机构信息
Division of Cardiovascular Medicine, Allegheny Health Network, 320, E. North Avenue, Pittsburgh, PA 15212, USA.
Division of Cardiovascular Medicine, Allegheny Health Network, 320, E. North Avenue, Pittsburgh, PA 15212, USA.
出版信息
J Clin Lipidol. 2022 May-Jun;16(3):253-260. doi: 10.1016/j.jacl.2022.02.005. Epub 2022 Feb 20.
Abstract
Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality in the US. Preeclampsia (PreE) which includes hypertension and proteinuria during pregnancy, is thought to result from placental ischemia. Risk factors for PreE parallel those for cardiovascular disease, and recent studies point to hyperlipidemia specifically, hypertriglyceridemia, as a risk factor for PreE. Current practice does not routinely include lipid testing pre-conception or during pregnancy. Professional, societal recommendations should advocate for hyperlipidemia screening, followed by appropriate management, pre-conception and during pregnancy.
摘要
妊娠高血压疾病是美国孕产妇发病率和死亡率的主要原因之一。子痫前期（PreE）是指妊娠期间出现高血压和蛋白尿，被认为是由胎盘缺血引起的。PreE 的风险因素与心血管疾病相似，最近的研究指出，高脂血症，特别是高甘油三酯血症，是 PreE 的一个风险因素。目前的实践并不常规包括在受孕前或怀孕期间进行脂质检测。专业和社会的建议应该倡导进行高脂血症筛查，然后在受孕前和怀孕期间进行适当的管理。
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2
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Hypertension. 2021 Aug;78(2):480-488. doi: 10.1161/HYPERTENSIONAHA.121.17104. Epub 2021 Jun 8.
3
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