Department of Endocrinology, Hospital Virgen de los Lirios Alcoy, 03804, Alicante, Spain.
Department of Endocrinology, Bernabéu Institute of Reproductive Medicine, 03016, Alicante, Spain.
Sci Rep. 2022 Mar 8;12(1):3704. doi: 10.1038/s41598-022-07592-8.
Radioactive iodine (I) is used after surgery in the treatment of Differentiated Thyroid Carcinoma (DTC). There is no solid evidence about the potential deleterious effect of I on women fertility. The objective of this study is to assess the impact that I may have on fertility in women. All women followed by DTC in our department have been analyzed and women younger than 45 years old at the time of diagnosis and initial treatment were included. There were 40 women exposed to I (study group) and 11 women who were only treated with thyroidectomy (control group). Of the women exposed to I, 40% went through early menopause, while no cases were reported among their controls. Furthermore, 29.2% of women exposed to I had decreased Antimüllerian Hormone (AMH), compared to the only 11% of unexposed women (not significant). Regarding the fertility impairment "perceived" by patients, in the group of women exposed to iodine, 17.9% described being unable to complete their genesic desire whereas, none was registered in the control group. We conclude that radioactive iodine can affect a woman's fertility and shorten her reproductive life, so this is an aspect that should be taken into consideration.
放射性碘（I）在分化型甲状腺癌（DTC）手术后用于治疗。目前尚无确凿证据表明 I 对女性生育能力有潜在的有害影响。本研究旨在评估 I 对女性生育能力可能产生的影响。我们科室随访的所有 DTC 女性，以及在诊断和初始治疗时年龄小于 45 岁的女性均被纳入分析。其中 40 名女性接受了 I 治疗（研究组），11 名仅接受了甲状腺切除术（对照组）。在接受 I 治疗的女性中，40%的人过早绝经，而对照组中没有这种情况。此外，29.2%的接受 I 治疗的女性抗苗勒管激素（AMH）降低，而未接受 I 治疗的女性只有 11%（无统计学意义）。关于患者“感知”到的生育能力受损，在接受碘治疗的女性组中，17.9%的人表示无法完成生育愿望，而对照组中则没有这种情况。我们得出结论，放射性碘会影响女性的生育能力并缩短其生殖寿命，因此这是一个需要考虑的方面。
