Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Clin Endocrinol (Oxf). 2022 Sep;97(3):319-330. doi: 10.1111/cen.14712. Epub 2022 Mar 16.
Polycystic ovary syndrome (PCOS) is associated with several cardiovascular risk factors. Prebiotics were proposed to beneficially affect risk factors associated with metabolic disorders. The aim of this study was to investigate and compare the effects of inulin-type fructans (ITFs), as well-studied prebiotics, with different degrees of polymerization, on markers of inflammation, oxidative stress and endothelial dysfunction in PCOS patients.
A randomized, double-blind, placebo-controlled trial.
Seventy-five PCOS women were randomly assigned to receive 10 g/day of either high-performance inulin (HPI) or oligofructose-enriched inulin (OEI) or placebo for 12 weeks.
Biochemical indices and blood pressure levelswere assessed before and after the intervention.
In the intent-to-treat analysis, high-sensitive C-reactive protein (hs-CRP) decreased in HPI and OEI groups, over the 12 weeks, and the changes were significant in the HPI group, compared to placebo (changes from baseline in the HPI group: -0.11 vs. placebo group: 0.004 mg/L [conversion factor to SI units (nmol/L): 9/5238]; p = .007). Serum levels of nitric oxide (NO) increased, and endothelin-1 and total oxidant status decreased in HPI and OEI groups, at the end of the trial; however, these changes were not significantly compared to placebo (p = .07, .36 and .22, respectively). No differences in systolic and diastolic blood pressure were found. Per-protocol analysis (n = 68) yielded consistent results for all endpoints, with the exception that the significant effect of ITFs on serum hs-CRP levels in the unadjusted ITT analysis became nonsignificant in the per-protocol analysis (p = .06).
A 12-week supplementation with long-chain ITFs had favourable effects on inflammatory status among PCOS patients.
多囊卵巢综合征（PCOS）与多种心血管危险因素相关。有研究提出，益生元可有益地影响与代谢紊乱相关的危险因素。本研究旨在调查和比较具有不同聚合度的菊粉型果聚糖（ITF）作为研究充分的益生元，对 PCOS 患者炎症标志物、氧化应激和内皮功能障碍的影响。
一项随机、双盲、安慰剂对照试验。
75 名 PCOS 女性患者被随机分为三组，分别接受 10 g/d 的高性能菊粉（HPI）、富含低聚果糖的菊粉（OEI）或安慰剂，干预持续 12 周。
在干预前后评估生化指标和血压水平。
在意向性治疗分析中，HPI 和 OEI 组的高敏 C 反应蛋白（hs-CRP）在 12 周内下降，与安慰剂组相比，HPI 组的变化更为显著（HPI 组从基线变化：-0.11 与安慰剂组：0.004mg/L[转换因子到 SI 单位（nmol/L）：9/5238]；p=0.007）。在试验结束时，HPI 和 OEI 组的血清一氧化氮（NO）水平升高，内皮素-1 和总氧化剂状态降低；然而，与安慰剂相比，这些变化无统计学意义（p=0.07、0.36 和 0.22）。收缩压和舒张压无差异。符合方案分析（n=68）对所有终点均得出一致的结果，除了 ITF 对未经调整的 ITT 分析中血清 hs-CRP 水平的显著影响在符合方案分析中变得无统计学意义（p=0.06）。
12 周补充长链 ITF 对 PCOS 患者的炎症状态有有利影响。
