Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute, Heritage Medical Research Building, Calgary, Alberta, Canada.
BENEO Institute c/o BENEO GmbH, Obrigheim/Pfalz, Germany.
Am J Clin Nutr. 2024 Nov;120(5):1245-1258. doi: 10.1016/j.ajcnut.2024.09.019. Epub 2024 Sep 21.
Excess body weight and adiposity can adversely affect metabolic health. Prebiotics such as inulin-type fructans (ITFs) from chicory root are known to modulate gut microbiota and may improve body weight regulation.
This study aimed to assess evidence for chicory ITF supplementation to support weight management.
Eligible articles (initial search to 2021, updated to February 2023) were searched from EMBASE, MEDLINE (PubMed), and Cochrane Library. Data on primary (body weight) and secondary outcomes [body mass index (BMI), total fat mass, body fat percentage, and waist circumference] were extracted by 2 reviewers independently. Random-effects model using inverse-variance method was used. Subgroup analysis (health status and ITF type) and meta-regression (dose and duration) were evaluated.
A total of 32 eligible studies were included. Chicory ITF significantly reduced body weight [mean difference (MD): -0.97 kg; 95% CI: -1.34, -0.59); n = 1184] compared with placebo. ITF favored overall effects reduction in BMI (MD: -0.39 kg/m; 95% CI: -0.57, -0.20; n = 985), fat mass (MD: -0.37 kg; 95% CI: -0.61, -0.13; n = 397), waist circumference (MD: -1.03 cm; 95% CI: -1.69, -0.37; n = 604), and for intervention duration of >8 wk, body fat percentage (MD: -0.78%; 95% CI: -1.17, -0.39; n = 488). Except for considerable heterogeneity in body weight (I: 73%) and body fat percentage (I: 75%), all other outcomes had negligible to moderate heterogeneity. Significant reduction in body weight, BMI, and waist circumference was evident irrespective of participants' health status. There was minimal evidence that dose, duration, or type of ITF influenced the magnitude of reductions in outcomes.
Chicory ITF supplementation may benefit weight management by reducing body weight, BMI, fat mass, waist circumference, and, to a certain extent, body fat percentage. This systematic review with meta-analysis was registered at PROSPERO as CRD42020184908.
超重和肥胖会对代谢健康产生不利影响。菊苣根中的菊糖型果聚糖（ITF）等益生元可以调节肠道微生物群，可能有助于控制体重。
本研究旨在评估菊苣 ITF 补充剂在支持体重管理方面的证据。
从 EMBASE、MEDLINE（PubMed）和 Cochrane 图书馆中检索符合条件的文章（初始搜索截至 2021 年，更新至 2023 年 2 月）。由 2 位审查员独立提取主要结局（体重）和次要结局[体重指数（BMI）、总脂肪量、体脂百分比和腰围]的数据。使用逆方差法的随机效应模型。进行了亚组分析（健康状况和 ITF 类型）和 meta 回归（剂量和持续时间）。
共纳入 32 项符合条件的研究。与安慰剂相比，菊苣 ITF 可显著降低体重[平均差（MD）：-0.97kg；95%置信区间（CI）：-1.34，-0.59）；n=1184]。ITF 有利于总体 BMI 降低的效果（MD：-0.39kg/m；95%CI：-0.57，-0.20；n=985）、脂肪量（MD：-0.37kg；95%CI：-0.61，-0.13；n=397）、腰围（MD：-1.03cm；95%CI：-1.69，-0.37；n=604），以及干预持续时间>8 周时的体脂百分比（MD：-0.78%；95%CI：-1.17，-0.39；n=488）。除体重（I：73%）和体脂百分比（I：75%）存在显著异质性外，其他所有结局的异质性均较小。无论参与者的健康状况如何，体重、BMI 和腰围的显著降低均有明显证据。证据表明，剂量、持续时间或 ITF 类型对结局降低的幅度影响不大。
菊苣 ITF 补充剂可能通过降低体重、BMI、脂肪量、腰围和在一定程度上降低体脂百分比来有益于体重管理。本系统评价和荟萃分析已在 PROSPERO 注册，注册号为 CRD42020184908。
