Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, OmegaHealth, Institut d'Epidémiologie et de Neurologie Tropicale, Limoges, France.
CHU Limoges, Cardio-surgical Intensive Care Unit, Limoges, France.
Echocardiography. 2022 Apr;39(4):576-583. doi: 10.1111/echo.15331. Epub 2022 Mar 8.
Reported ranges of normal values are mostly issued from studies performed with Caucasians. This study is a part of TAHES, a population-based prospective cohort study in Benin and aims to establish normal reference values for echocardiographic diameters of the proximal aorta in Africans.
Transthoracic echocardiography (TTE) examinations were performed by four cardiologists following pre-defined protocols, and analyzed off-line by a single observer. Aortic root diameters were measured during diastole for sinuses of Vasalva (SV), sinotubular junction (STJ) and proximal ascending aorta (AA), and during systole for annulus. Upper limits were defined as the 95th percentiles.
We included 513 normotensive, non-diabetic, and cardiovascular disease-free individuals (206 men, 307 women, age 40 ± 14 years). The diameters of the proximal aorta were significantly greater in men. The inner-edge-to-inner-edge non-indexed upper values for the annulus, SV, STJ and AA were respectively 25, 34, 28.5, 32 mm in men and 22, 30, 26, 30 mm in women. The leading-edge-to-leading-edge upper values were respectively 38, 35, 36 for men and 34, 33, 32 mm for women. No significant differences between sexes were recorded for body surface area (BSA)-indexed diameters of the annulus, STJ and AA. BSA-indexed SV dimension was greater in men than women were. SV, STJ, AA indexed-diameters correlated with age in both sexes but not for annulus indexed-diameter.
Normal values from a general population in West Africa could to differ from those established in Caucasian populations. Ethnic-specific reference diameters are here proposed for appropriate diagnosis of proximal aortic diseases in sub-Saharan Africa.
正常值的报告范围主要来自于针对白种人的研究。本研究是 TAHES 的一部分，这是一项在贝宁进行的基于人群的前瞻性队列研究，旨在为非洲人近端主动脉的超声心动图直径建立正常参考值。
四名心脏病专家按照预先确定的方案进行经胸超声心动图（TTE）检查，并由一名观察者进行离线分析。主动脉根部直径在舒张期测量窦部（SV）、窦管交界（STJ）和近端升主动脉（AA），在收缩期测量瓣环。上限定义为第 95 个百分位。
我们纳入了 513 名血压正常、非糖尿病且无心血管疾病的个体（206 名男性，307 名女性，年龄 40±14 岁）。男性近端主动脉直径明显更大。男性瓣环、SV、STJ 和 AA 的内缘到内缘非指数上限值分别为 25、34、28.5 和 32mm，女性分别为 22、30、26 和 30mm。前缘到前缘的上限值分别为男性 38、35、36mm，女性 34、33、32mm。男女之间瓣环、STJ 和 AA 的体表面积（BSA）指数直径无显著差异。男性的 BSA 指数 SV 直径大于女性。SV、STJ 和 AA 的 BSA 指数直径在两性中均与年龄相关，但瓣环的 BSA 指数直径与年龄无关。
来自西非一般人群的正常值可能与白种人群体的正常值不同。这里提出了特定种族的参考直径，以便在撒哈拉以南非洲地区对近端主动脉疾病进行适当的诊断。
