Van Sluys M A, Alcantara-Gomes R, Menck C F
Mutat Res. 1986 Aug;174(4):265-9. doi: 10.1016/0165-7992(86)90045-x.
Ascorbate (vitamin C) in the presence of copper yields H2O2, which seems to be responsible for its toxic effects in bacteria. However, we found that the Escherichia coli xthA mutant strain, which is hypersensitive to H2O2, has almost the same sensitivity as the wild-type strain to ascorbate and copper treatment. Our results suggest that the DNA damage induced in E. coli by H2O2 generated in oxidized ascorbate solutions is different from that induced by direct H2O2 treatment.
在铜存在的情况下，抗坏血酸盐（维生素C）会产生过氧化氢，这似乎是其对细菌产生毒性作用的原因。然而，我们发现对过氧化氢高度敏感的大肠杆菌xthA突变株，在抗坏血酸盐和铜处理下与野生型菌株的敏感性几乎相同。我们的结果表明，氧化抗坏血酸溶液中产生的过氧化氢在大肠杆菌中诱导的DNA损伤与直接用过氧化氢处理诱导的DNA损伤不同。
