大肠杆菌xth突变体对过氧化氢高度敏感。
Escherichia coli xth mutants are hypersensitive to hydrogen peroxide.
作者信息
Demple B, Halbrook J, Linn S
出版信息
J Bacteriol. 1983 Feb;153(2):1079-82. doi: 10.1128/jb.153.2.1079-1082.1983.
Abstract
Escherichia coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-induced lethality and the in vivo role of exonuclease III.
摘要
缺乏核酸外切酶III（xthA）的大肠杆菌突变体对过氧化氢异常敏感。它们被过氧化氢杀死的速度是野生型细菌的20倍，是recA细胞的3至4倍。这是首次报道的xth-大肠杆菌明确的表型敏感性，应有助于阐明过氧化物诱导的致死性以及核酸外切酶III在体内的作用。
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