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In vivo time course of synthesis and processing of major schizont membrane polypeptides in Plasmodium falciparum.

作者信息

Braun-Breton C, Jendoubi M, Brunet E, Perrin L, Scaife J, Pereira da Silva L

出版信息

Mol Biochem Parasitol. 1986 Jul;20(1):33-43. doi: 10.1016/0166-6851(86)90140-4.

DOI:10.1016/0166-6851(86)90140-4
PMID:3526146
Abstract

A rapid method of separating membrane co-sedimentable and soluble components of Plasmodium infected erythrocytes is presented. We propose a nomenclature for major P. falciparum polypeptides, applicable to different isolates and based on their cellular location and stage specificity. For four of these polypeptides (185 kDa = Mp1; 120 kDa = Mp3; 76 kDa = Mp5; 90 kDa= Sp2) supposed to play a role in protective immunity, monospecific antibodies were available. We have studied their fate at the time of merozoïte release and reinvasion, and the possible correlations between these polypeptides, by pulse-chase experiments.

摘要

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