Miettinen-Baumann A, Strych W, McBride J, Heidrich H G
Max-Planck-Institut für Biochemie, Martinsried, Federal Republic of Germany.
Parasitol Res. 1988;74(4):317-23. doi: 10.1007/BF00539452.
A 46,000 dalton glycoprotein was isolated by extraction of freshly harvested P. falciparum merozoites (FCB1 strain), followed by gel electrophoresis of the extract and electroelution. The antigen is present in the late ring, trophozoite, schizont, and segmenter stages and is localized on the merozoite surface at the end of schizogony. It is not related to the 185,000-195,000 dalton schizont antigen. An antiserum against the 46,000 dalton antigen inhibits invasion of erythrocytes by merozoites. The isolated antigen is identical to the antigen against which monoclonal antibody (mcab) 13.4 is directed.
通过提取新鲜收获的恶性疟原虫裂殖子（FCB1株），然后对提取物进行凝胶电泳和电洗脱，分离出一种46000道尔顿的糖蛋白。该抗原存在于晚期环状体、滋养体、裂殖体和裂殖子阶段，在裂体生殖结束时定位于裂殖子表面。它与185000 - 195000道尔顿的裂殖体抗原无关。针对46000道尔顿抗原的抗血清可抑制裂殖子对红细胞的侵袭。分离出的抗原与单克隆抗体（mcab）13.4所针对的抗原相同。
