Morphological and immunohistochemical study in Hodgkin's disease.

Histogenesis of different microscopical types of Hodgkin's disease was investigated in a series of 19 patients by morphological and immunohistochemical methods. The main changes affecting the lymphatic system occur in perivascular areas, which contain a great amount of thymic factor. The Hodgkin's and Reed-Sternberg cells appear to arise from the perivascular mesenchyme and some of them have cross-striated cytoplasm.