Kim Jisu, Li Shiyi, Zhang Shuya, Wang Jianxin
Department of Pharmaceutics, School of Pharmacy, Ministry of Education, Fudan University & Key Laboratory of Smart Drug Delivery, Shanghai 201203, China.
Institute of Integrated Chinese and Western Medicine, Fudan University, Shanghai 200040, China.
Asian J Pharm Sci. 2022 Jan;17(1):53-69. doi: 10.1016/j.ajps.2021.05.006. Epub 2021 Jul 10.
Nanotechnologies have been successfully applied to the treatment of various diseases. Plant-derived exosome-like nanoparticles (PENs) are expected to become effective therapeutic modalities for treating disease or in drug-delivery. PENs are minimally cytotoxic to healthy tissues, with which they show excellent biocompatibility, and are biased towards tumors by targeting specific tissues through special endocytosis mechanisms. Thus, the use of these PENs may expand the scope of drug therapies while reducing the off-target effects. In this review, we summarize the fundamental features and bioactivities of PENs extracted from the grape, grapefruit, ginger, lemon, and broccoli and discuss the applications of these particles as therapeutics and nanocarriers.
纳米技术已成功应用于各种疾病的治疗。植物来源的外泌体样纳米颗粒（PENs）有望成为治疗疾病或药物递送的有效治疗方式。PENs对健康组织的细胞毒性极小，具有出色的生物相容性，并且通过特殊的内吞机制靶向特定组织，从而偏向于肿瘤。因此，使用这些PENs可能会扩大药物治疗的范围，同时减少脱靶效应。在本综述中，我们总结了从葡萄、柚子、生姜、柠檬和西兰花中提取的PENs的基本特征和生物活性，并讨论了这些颗粒作为治疗剂和纳米载体的应用。
