生物工程纳米技术在核酸传递中的应用。
Bioengineered nanotechnology for nucleic acid delivery.
机构信息
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China; Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Department of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
J Control Release. 2023 Dec;364:124-141. doi: 10.1016/j.jconrel.2023.10.034. Epub 2023 Oct 27.
Nucleic acid-based therapy has emerged as a promising therapeutic approach for treating various diseases, such as genetic disorders, cancers, and viral infections. Diverse nucleic acid delivery systems have been reported, and some, including lipid nanoparticles, have exhibited clinical success. In parallel, bioengineered nucleic acid delivery nanocarriers have also gained significant attention due to their flexible functional design and excellent biocompatibility. In this review, we summarize recent advances in bioengineered nucleic acid delivery nanocarriers, focusing on exosomes, cell membrane-derived nanovesicles, protein nanocages, and virus-like particles. We highlight their unique features, advantages for nucleic acid delivery, and biomedical applications. Furthermore, we discuss the challenges that bioengineered nanocarriers face towards clinical translation and the possible avenues for their further development. This review ultimately underlines the potential of bioengineered nanotechnology for the advancement of nucleic acid therapy.
核酸治疗作为一种有前途的治疗方法，已经被广泛应用于治疗各种疾病，如遗传疾病、癌症和病毒感染等。目前已经报道了多种核酸递送系统，其中一些如脂质纳米粒已经在临床上取得了成功。与此同时，基于生物工程的核酸递送纳米载体也因其灵活的功能设计和优异的生物相容性而受到了广泛关注。在这篇综述中，我们总结了生物工程核酸递送纳米载体的最新进展，重点介绍了外泌体、细胞膜衍生纳米囊泡、蛋白纳米笼和病毒样颗粒。我们强调了它们独特的特性、核酸递送的优势以及在生物医学领域的应用。此外，我们还讨论了生物工程纳米载体在临床转化中面临的挑战以及进一步发展的可能途径。这篇综述最终强调了生物工程纳米技术在核酸治疗中的应用前景。
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