Cuvelier R, Pirson Y, Cosyns J P, Squifflet J P, Alexandre G P, van Ypersele de Strihou C
Nephrologie. 1986;7(2):63-6.
Renal transplantation was performed in five patients with various forms of amyloidosis (familial amyloidosis, Mediterranean fever and Crohn's disease). All grafts were functioning one year after the operation. Only one patient died of cardiac shock more than 10 years after transplantation; the other recipients are alive with a functioning graft from 12 to 67 (mean, 41) months after transplantation. No early severe infection was observed in any patient. Graft biopsy obtained in three patients disclosed amyloid deposits in only one: deposits initially (72 months post-transplantation) mild and perivascular, became more prominent in the vessels and extended into the mesangium 4 1/2 years later. Extrarenal amyloid involvement observed in four cases did not lead to serious clinical consequences during the follow-up period. Renal transplantation thus provides an effective treatment of terminal renal failure due to amyloidosis whatever its cause.
对五名患有各种形式淀粉样变性（家族性淀粉样变性、地中海热和克罗恩病）的患者进行了肾移植。所有移植肾在术后一年均功能良好。只有一名患者在移植后10多年死于心源性休克；其他受者在移植后12至67个月（平均41个月）移植肾功能良好且存活。未观察到任何患者发生早期严重感染。在三名患者中进行的移植肾活检仅在一名患者中发现了淀粉样沉积物：最初（移植后72个月）沉积物轻微且位于血管周围，4年半后在血管中变得更加明显并延伸至系膜。在随访期间，观察到的4例肾外淀粉样变性累及未导致严重的临床后果。因此，无论病因如何，肾移植都为因淀粉样变性导致的终末期肾衰竭提供了一种有效的治疗方法。
