School of Physics, University of Electronic Science and Technology of China, Chengdu 611731, China.
Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
Nanoscale. 2022 Mar 24;14(12):4671-4678. doi: 10.1039/d1nr08168c.
A self-powered wearable brain-machine-interface system with pulse detection and brain stimulation for ceasing action has been realized. The system is composed of (1) a power supply unit that employs a piezoelectric generator and converts the mechanical energy of human daily activities into electricity; (2) a neck pulse biosensor that allows continuous measurements of carotid pulse by using a piezoelectric polyvinylidene fluoride film; (3) a data analysis module that enables a coordinated brain-machine-interface system to output brain stimulation signals; and (4) brain stimulating electrodes linked to the brain that implement behavioral intervention. Demonstration of the system with stimulating electrodes implanted in the periaqueductal gray (PAG) in running mice reveals the great effect of forced ceasing action. The mice stop their running within several seconds when the stimulation signals are sent into the PAG brain region (inducing fear). This self-powered scheme for neural stimulation realizes specific behavioral intervention without any external power supply, thus providing a new concept for future behavior intervention.
已实现一种具有脉冲检测和大脑刺激功能的自供电可穿戴脑机接口系统，用于停止动作。该系统由（1）一个电源单元组成，该单元采用压电发电机，将人体日常活动的机械能转化为电能；（2）一个颈部脉搏生物传感器，它使用压电聚偏二氟乙烯薄膜实现对颈动脉脉搏的连续测量；（3）数据分析模块，使协调的脑机接口系统能够输出脑刺激信号；（4）与大脑相连的大脑刺激电极，实现行为干预。通过在跑动的小鼠中植入刺激电极来演示该系统，揭示了强制停止动作的巨大效果。当刺激信号被发送到中脑导水管周围灰质（PAG）脑区时（引起恐惧），小鼠在几秒钟内停止跑动。这种用于神经刺激的自供电方案实现了特定的行为干预，而无需任何外部电源，为未来的行为干预提供了新的概念。
