School of Physics, University of Electronic Science and Technology of China, Chengdu 611731, China.
Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China.
Nanoscale. 2022 Sep 2;14(34):12483-12490. doi: 10.1039/d2nr03115a.
Heat stroke that may cause acute central nervous system dysfunction, multiple organ dysfunction and even death has become a typical health problem in tropical developing countries. The primary goal of heat stroke treatment is to lower core body temperature, which necessitates physical or medical cooling in time. Here, we design a new self-powered wearable brain-machine-interface system for real-time monitoring and regulating body temperature. This system can monitor body temperature in real time and transmit neural electrical stimulation signals into specific brain regions to lower the body temperature. The whole system can work without an external power supply and be powered by the body itself through the piezoelectric effect. The system comprises a temperature detecting unit, a power supply unit, a data processing module, and a brain stimulator. Demonstration of the system with stimulation electrodes implanted in the median preoptic nucleus brain region in mice reveals an evident decrease in body temperature (1.0 °C within 15 min). This self-powered strategy provides a new concept for future treatment of heat stroke and can extend the application of brain-machine-interface systems in medical care.
热射病可能导致急性中枢神经系统功能障碍、多器官功能障碍甚至死亡，已成为热带发展中国家的一个典型健康问题。热射病治疗的首要目标是降低核心体温，这需要及时进行物理或医疗降温。在这里，我们设计了一种新的自供电可穿戴脑机接口系统，用于实时监测和调节体温。该系统可以实时监测体温，并将神经电刺激信号传输到特定的脑区以降低体温。整个系统无需外部电源，而是通过压电效应利用人体自身供电。该系统包括温度检测单元、电源单元、数据处理模块和脑刺激器。在植入中脑视前核脑区的刺激电极的小鼠中进行系统演示，结果显示体温明显下降（15 分钟内降低 1.0°C）。这种自供电策略为未来热射病的治疗提供了新的概念，并可以扩展脑机接口系统在医疗保健中的应用。
