School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Mengxi Road No. 2, Zhenjiang, 212003, P. R. China.
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China.
Org Biomol Chem. 2022 Mar 23;20(12):2356-2369. doi: 10.1039/d2ob00126h.
Enaminones and analogous stable enamines are well known as platform building blocks in organic synthesis for the construction of heterocyclic compounds, especially N-heterocycles. To date, enaminones have been successfully employed in the synthesis of various 5- or 6- membered heterocycles. Recently, synthetic protocols accomplished by diversity-oriented annulation reactions based on the C-N bond cleavage of enamines have gained notable success. In this review, the development of the transition metal-free heterocyclic product synthesis based on the annulation reactions of enaminones or analogous enamines featuring a C-N bond cleavage is reviewed.
烯胺酮和类似的稳定烯胺是有机合成中构建杂环化合物，特别是 N-杂环化合物的平台构建块，这是众所周知的。迄今为止，烯胺酮已成功用于各种 5 或 6 元杂环的合成。最近，基于烯胺的 C-N 键断裂的多样性导向环化反应的合成方案取得了显著的成功。在本文综述中，综述了基于 C-N 键断裂的烯胺酮或类似烯胺的环化反应来合成过渡金属自由杂环产物的发展。
