Department of Radiology, Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Obstetrics and Gynecology, Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Ultrasound. 2022 Dec;25(4):949-955. doi: 10.1007/s40477-022-00670-7. Epub 2022 Mar 9.
This study aimed at evaluating the value of uterine biophysical profile (UBP) scoring to predict the pregnancy rate after IUI.
This prospective study was carried out on 85 women who were referred to our tertiary teaching center with infertility of male factor or unknown etiology infertility in 2018. To measure the uterine biophysical criteria, transvaginal ultrasonography (TVS) was performed on the day of beta-human chorionic gonadotropin (B-hCG) injection, and the results were evaluated based on positive B-hCG.
85 patients were included with a mean age of 30 years; of those 12 (14.1%) were able to conceive. UBP (p = 0.151) and it's parameters (including endometrial thickness, number of endometrial layers, myometrial echogenicity, uterine artery pulsatility index, myometrial blood flow internal to arcuate vessels, endometrial blood flow in the third zone of endometrium, myometrial contraction frequency, and ovarian follicle (OF) size [p = 0.05, 0.89, 0.59, 0.79, 1, 1, 0.59, and 0.77, respectively]) were not significantly associated with pregnancy rate. 91.7% of the cases with positive pregnancy test results, had a UBP score of > 13; however, UBP score was not meaningfully associated with IUI treatment success rate (p = 0.15).
UBP scoring system seems to need more data for external validation, or it might require modifications before implementation, as it may cause false reassurance.
本研究旨在评估子宫生物物理评分（UBP）在预测 IUI 后妊娠率方面的价值。
本前瞻性研究于 2018 年在我院接受男性因素或不明原因不孕的 85 名女性中进行。为了测量子宫生物物理标准，在注射人绒毛膜促性腺激素（β-hCG）当天进行经阴道超声（TVS）检查，并根据阳性β-hCG 评估结果。
85 例患者入选，平均年龄 30 岁；其中 12 例（14.1%）成功受孕。UBP（p=0.151）及其参数（包括子宫内膜厚度、子宫内膜层数、子宫肌层回声、子宫动脉搏动指数、子宫弧形血管内肌层血流、子宫内膜第三层血流、子宫肌层收缩频率和卵巢卵泡（OF）大小[p=0.05、0.89、0.59、0.79、1、1、0.59 和 0.77]）与妊娠率无显著相关性。91.7%的妊娠试验阳性病例的 UBP 评分>13；然而，UBP 评分与 IUI 治疗成功率无显著相关性（p=0.15）。
UBP 评分系统似乎需要更多的外部验证数据，或者在实施前可能需要修改，因为它可能会导致错误的保证。
