St Michael's Hospital, Bristol, UK.
J Assist Reprod Genet. 2013 Jun;30(5):667-71. doi: 10.1007/s10815-013-9980-6. Epub 2013 Mar 29.
To summarise the causes of decreased fecundity with age and review chronological vs biological ovarian ageing. To explore the clinician's means of assessing a woman's ovarian reserve. To review the recent literature on the effectiveness of different assisted reproductive technology (ART) techniques for women aged 40 and over and offer a single best treatment option.
Pubmed and google scholar were searched for relevant articles using key words. Data were extracted based on authors, year, aims, sample and results.
Success rates for women aged 40 or over with clomiphene, IUI, IUI with FSH are all extremely low, at less than 1% live birth per cycle. However, IVF offers a success rate of around 13.7% per cycle.
An exploration of the effectiveness of available treatment options for older infertile women using their own gametes suggests that IVF offers the best prospects of success. Attempting treatments other than IVF will delay conception unnecessarily.
总结年龄导致生育能力下降的原因，回顾生理年龄与实际年龄的卵巢老化。探讨评估女性卵巢储备功能的临床方法。回顾最近关于 40 岁及以上女性不同辅助生殖技术（ART）技术有效性的文献，并提供单一最佳治疗选择。
使用关键词在 Pubmed 和谷歌学术上搜索相关文章。根据作者、年份、目的、样本和结果提取数据。
40 岁或以上接受克罗米酚、IUI、FSH 联合 IUI 的女性的成功率都极低，每个周期活产率不到 1%。然而，IVF 的成功率约为每周期 13.7%。
对使用自身配子的老年不孕女性的可用治疗选择的有效性进行探讨表明，IVF 提供了最佳的成功前景。尝试 IVF 以外的治疗方法将不必要地延迟受孕。
