Department of Dermatology, Venereology and Allergology.
Institute of Clinical Immunology, University of Leipzig, Leipzig, 04103, Germany.
Br J Dermatol. 2022 Sep;187(3):419-422. doi: 10.1111/bjd.21229. Epub 2022 May 20.
Here we present another family with CARD14-associated papulosquamous eruption, which is characterized by mutations in CARD14 and skin lesions resembling psoriasis and pityriasis rubra pilaris. We show beneficial therapeutic response to anti-IL17A treatment in one patient and performed immunomonitoring of our patient, exhibiting enhanced pSTAT3 levels in T cells before treatment, which normalized after treatment. Together, our data support the pathogenic role of IL-17A in this disease, which might have consequences for future treatment decisions in this rare condition.
在这里，我们呈现了另一个家族性 CARD14 相关的丘疹鳞屑性疹，其特征为 CARD14 突变和类似银屑病和毛发红糠疹样的皮肤损伤。我们展示了一位患者对抗 IL-17A 治疗的有益治疗反应，并对我们的患者进行了免疫监测，在治疗前 T 细胞中显示增强的 pSTAT3 水平，治疗后恢复正常。总之，我们的数据支持 IL-17A 在这种疾病中的致病作用，这可能对这种罕见疾病的未来治疗决策产生影响。
