能量转移介导的光催化实现的催化脱羧氟磺酰化反应。
Catalytic Decarboxylative Fluorosulfonylation Enabled by Energy-Transfer-Mediated Photocatalysis.
机构信息
Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China.
出版信息
Org Lett. 2022 Apr 8;24(13):2474-2478. doi: 10.1021/acs.orglett.2c00459. Epub 2022 Mar 9.
Sulfonyl fluorides are useful building blocks in a wide array of fields. Herein, we report a catalytic decarboxylative fluorosulfonylation approach for converting abundant aliphatic carboxylic acids to the corresponding sulfonyl fluorides. This transformation is enabled by simple preactivation as aldoxime esters and energy-transfer-mediated photocatalysis. This operationally simple method proceeds with high functional-group tolerance under mild and redox-neutral conditions.
磺酰氟是广泛领域中非常有用的构建模块。在此，我们报告了一种催化脱羧氟磺酰化方法，可将丰富的脂肪族羧酸转化为相应的磺酰氟化物。这种转化通过简单的预激活作为醛肟酯和能量转移介导的光催化来实现。这种操作简单的方法在温和和氧化还原中性条件下具有高官能团耐受性。
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