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[胰岛素在调节肾脏对葡萄糖的肾小管重吸收中的作用]

[Role of insulin in the regulation of the tubular reabsorption of glucose in the kidneys].

作者信息

Briukhanov V M

出版信息

Probl Endokrinol (Mosk). 1986 May-Jun;32(3):62-5.

PMID:3526319
Abstract

Glucose tubular transport in the kidneys in changes of insulin concentration in the blood was studied in acute and chronic experiments on dogs. Maximum glucose reabsorption in the kidneys was shown to remain unchanged in the stimulation of insulin secretion or depletion of insular function (alloxan diabetes). Neither did the administration of insulin into the renal artery at doses of 0.02-0.04 U/min for 30 min. influence glucose reabsorption which rose during hormone infusion at doses of 0.4-0.5 U/min only.

摘要

在对狗进行的急性和慢性实验中,研究了血液中胰岛素浓度变化时肾脏中葡萄糖的肾小管转运情况。结果表明,在刺激胰岛素分泌或胰岛功能耗竭(四氧嘧啶糖尿病)时,肾脏中的最大葡萄糖重吸收保持不变。以0.02 - 0.04单位/分钟的剂量向肾动脉注射胰岛素30分钟,也不会影响葡萄糖重吸收,只有当胰岛素以0.4 - 0.5单位/分钟的剂量输注时,葡萄糖重吸收才会增加。

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