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NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation.在体外T细胞去除的单倍体同基因干细胞移植中,自然杀伤细胞含量似乎并不影响植入。
Stem Cell Reports. 2022 Mar 8;17(3):443-445. doi: 10.1016/j.stemcr.2022.02.006.
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Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation.对自然杀伤细胞含量的反应似乎不影响体外T细胞去除的单倍体同基因干细胞移植中的植入。
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NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation.自然杀伤细胞同种异体反应性与异基因造血干细胞移植
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Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children.重建自然杀伤细胞受体可影响儿童 T 细胞和 B 细胞耗竭移植物 HLA 单倍体移植后的自然杀伤细胞活性和复发率。
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1
Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation.对自然杀伤细胞含量的反应似乎不影响体外T细胞去除的单倍体同基因干细胞移植中的植入。
Stem Cell Reports. 2022 Mar 8;17(3):446-447. doi: 10.1016/j.stemcr.2022.02.007.

本文引用的文献

1
TCRαβ/CD19 depleted HSCT from an HLA-haploidentical relative to treat children with different nonmalignant disorders.用 HLA 单倍体相合的亲缘供者 TCRαβ/CD19 耗竭的 HSCT 治疗不同非恶性疾病的儿童。
Blood Adv. 2022 Jan 11;6(1):281-292. doi: 10.1182/bloodadvances.2021005628.
2
Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma.抑制自然杀伤细胞衍生的干扰素-γ可改善造血干细胞移植。
Stem Cell Reports. 2021 Aug 10;16(8):1999-2013. doi: 10.1016/j.stemcr.2021.06.008. Epub 2021 Jul 8.
3
Natural killer cells play an important role in virus infection control: Antiviral mechanism, subset expansion and clinical application.自然杀伤细胞在病毒感染控制中发挥重要作用:抗病毒机制、亚群扩增及临床应用。
Clin Immunol. 2021 Jun;227:108727. doi: 10.1016/j.clim.2021.108727. Epub 2021 Apr 20.
4
The role of interferon-gamma and its signaling pathway in pediatric hematological disorders.γ干扰素及其信号通路在儿科血液系统疾病中的作用。
Pediatr Blood Cancer. 2021 Apr;68(4):e28900. doi: 10.1002/pbc.28900. Epub 2021 Jan 23.
5
Improved survival and graft function in ex vivo T-cell depleted haploidentical hematopoietic cell transplantation for primary immunodeficiency.在原发性免疫缺陷的体外T细胞去除单倍体造血细胞移植中提高生存率和移植物功能。
Bone Marrow Transplant. 2021 May;56(5):1200-1204. doi: 10.1038/s41409-020-01152-2. Epub 2020 Nov 24.
6
Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.埃马珠单抗治疗原发性噬血细胞性淋巴组织细胞增生症患儿。
N Engl J Med. 2020 May 7;382(19):1811-1822. doi: 10.1056/NEJMoa1911326.
7
Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation.干扰素-γ 在异基因造血干细胞移植后免疫介导的移植物失败中的作用。
Haematologica. 2019 Nov;104(11):2314-2323. doi: 10.3324/haematol.2019.216101. Epub 2019 Feb 21.
8
Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion.αβ T 细胞和 B 细胞耗竭后 HLA 单倍体相合 HSCT 治疗急性白血病患儿的结果。
Blood. 2017 Aug 3;130(5):677-685. doi: 10.1182/blood-2017-04-779769. Epub 2017 Jun 6.
9
Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia.亲缘单倍体供者 CD3/CD19 耗竭的同种异体移植物在儿科白血病中的移植。
Br J Haematol. 2014 Jun;165(5):688-98. doi: 10.1111/bjh.12810. Epub 2014 Mar 4.
10
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.供体自然杀伤细胞同种异体反应性在不匹配造血移植中的有效性。
Science. 2002 Mar 15;295(5562):2097-100. doi: 10.1126/science.1068440.

NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation.

作者信息

Merli Pietro, Eichholz Thomas, Catanoso Maria Luigia, Lang Peter, Locatelli Franco

机构信息

Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Children's University Hospital, Eberhard Karls University Tübingen, Tübingen, Germany.

出版信息

Stem Cell Reports. 2022 Mar 8;17(3):443-445. doi: 10.1016/j.stemcr.2022.02.006.

DOI:10.1016/j.stemcr.2022.02.006
PMID:35263571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9039855/
Abstract
摘要