Regional Rehabilitation Centre, Queen Silvia Children's Hospital, Gothenburg, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Obes Facts. 2022;15(3):305-320. doi: 10.1159/000523943. Epub 2022 Mar 9.
Children and adolescents with autism spectrum disorder (ASD) appear to be at greater risk of excess weight gain. The aim of this systematic review and meta-analysis was to examine whether children with ASD have a greater prevalence of obesity and whether the prevalence of ASD is higher in children with obesity.
We conducted a systematic search on PubMed, Scopus, and PsychINFO until May 21, 2021. We used the meta package in the R in order to calculate the pooled prevalence and relative risk of obesity in children with ASD.
We found 20 eligible studies investigating the prevalence of obesity in children with ASD, with the prevalence ranging from 7.9 to 31.8% and from 1.4 to 23.6% among controls. All but three studies originated from the USA. The proportion of children with obesity in ASD populations was 17% (95% confidence interval [CI]: 13-22). The relative risk of obesity in children with ASD compared with control children was 1.58 (95% CI: 1.34-1.86). There were no controlled studies reporting on the prevalence of ASD in children with obesity.
Children and adolescents with ASD have a higher prevalence of obesity than healthy controls. There is a need for further prevalence studies of obesity in children with ASD, especially outside the USA, since the few European studies carried out have failed to show a significant difference between obesity prevalence in children with and without ASD. There is no knowledge at all regarding the prevalence of ASD among children with obesity.
自闭症谱系障碍（ASD）儿童和青少年似乎面临更大的体重增加风险。本系统回顾和荟萃分析旨在检查自闭症儿童是否存在肥胖的更高患病率，以及肥胖儿童中 ASD 的患病率是否更高。
我们在 2021 年 5 月 21 日之前在 PubMed、Scopus 和 PsychINFO 上进行了系统搜索。我们使用 R 中的 meta 包来计算自闭症儿童肥胖症的合并患病率和相对风险。
我们发现了 20 项研究，这些研究调查了自闭症儿童肥胖症的患病率，患病率从 7.9%到 31.8%不等，对照组的患病率从 1.4%到 23.6%不等。除了三项研究外，所有研究都来自美国。自闭症患者中肥胖儿童的比例为 17%（95%置信区间：13-22）。与对照组儿童相比，自闭症儿童肥胖的相对风险为 1.58（95%置信区间：1.34-1.86）。没有对照研究报告肥胖儿童中 ASD 的患病率。
自闭症儿童和青少年肥胖的患病率高于健康对照组。需要进一步开展自闭症儿童肥胖症的患病率研究，特别是在美国以外的地区，因为进行的少数欧洲研究未能显示自闭症儿童和无自闭症儿童肥胖症患病率之间存在显著差异。至于肥胖儿童中 ASD 的患病率，我们一无所知。
