Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia.
Department of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Hafar Al-Batin, Kingdom of Saudi Arabia.
Curr Pharm Biotechnol. 2022;23(12):1483-1496. doi: 10.2174/1389201023666220309152340.
Burn injuries are extremely debilitating, resulting in high morbidity and mortality rates around the world. The risk of infection escalates in correlation with impairment of skin integrity, creating a barrier to healing and possibly leading to sepsis. With its numerous advantages over traditional treatment methods, nanomaterial-based wound healing has an immense capability of treating and preventing wound infections. Carbon-based nanomaterials (CNMs), owing to their distinctive physicochemical and biological properties, have emerged as promising platforms for biomedical applications. Carbon nanotubes, graphene, fullerenes, and their nanocomposites have demonstrated broad antimicrobial activity against invasive bacteria, fungi, and viruses causing burn wound infection. The specific mechanisms that govern the antimicrobial activity of CNMs must be understood in order to ensure the safe and effective incorporation of these structures into biomaterials. However, it is challenging to decouple individual and synergistic contributions of the physical, chemical, and electrical effects of CNMs on cells. This review reported significant advances in the application of CNMs in burn wound infection and wound healing, with a brief discussion on the interaction between different families of CNMs and microorganisms to assess antimicrobial performance.
烧伤是极其致残的，导致全球发病率和死亡率居高不下。皮肤完整性受损会导致感染风险上升，阻碍愈合，并可能导致败血症。基于纳米材料的伤口愈合具有治疗和预防伤口感染的巨大潜力，它优于传统治疗方法。碳基纳米材料（CNMs）由于其独特的物理化学和生物学特性，已成为生物医学应用的有前途的平台。碳纳米管、石墨烯、富勒烯及其纳米复合材料对引起烧伤感染的侵袭性细菌、真菌和病毒表现出广泛的抗菌活性。为了确保将这些结构安全有效地纳入生物材料，必须了解控制 CNM 抗菌活性的具体机制。然而，要分离 CNM 的物理、化学和电学效应对细胞的单独和协同作用具有挑战性。本综述报道了 CNMs 在烧伤创面感染和创面愈合中的应用的重要进展，并简要讨论了不同家族的 CNMs 与微生物之间的相互作用，以评估其抗菌性能。
