Deshmukh Rohitas, Singh Vaibhav, Harwansh Ranjit K, Agrawal Rutvi, Garg Akash, Singh Sudarshan, Elossaily Gehan M, Ansari Mohd Nazam, Ali Nemat, Prajapati Bhupendra G
Institute of Pharmaceutical Research, GLA University, Mathura 281406, India.
Rajiv Academy for Pharmacy, Mathura 281001, India.
Pharmaceutics. 2024 Feb 20;16(3):297. doi: 10.3390/pharmaceutics16030297.
Prostate cancer is one of the most life-threatening disorders that occur in males. It has now become the third most common disease all over the world, and emerging cases and spiking mortality rates are becoming more challenging day by day. Several approaches have been used to treat prostate cancer, including surgery, radiation therapy, chemotherapy, etc. These are painful and invasive ways of treatment. Primarily, chemotherapy has been associated with numerous drawbacks restricting its further application. The majority of prostate cancers have the potential to become castration-resistant. Prostate cancer cells exhibit resistance to chemotherapy, resistance to radiation, ADT (androgen-deprivation therapy) resistance, and immune stiffness as a result of activating tumor-promoting signaling pathways and developing resistance to various treatment modalities. Nanomedicines such as liposomes, nanoparticles, branched dendrimers, carbon nanotubes, and quantum dots are promising disease management techniques in this context. Nanomedicines can target the drugs to the target site and enhance the drug's action for a prolonged period. They may also increase the solubility and bioavailability of poorly soluble drugs. This review summarizes the current data on nanomedicines for the prevention and treatment of prostate cancer. Thus, nanomedicine is pioneering in disease management.
前列腺癌是男性中最危及生命的疾病之一。它现已成为全球第三大常见疾病，新发病例和不断攀升的死亡率日益严峻。治疗前列腺癌的方法有多种，包括手术、放射治疗、化疗等。这些都是痛苦且具有侵入性的治疗方式。首先，化疗存在诸多弊端，限制了其进一步应用。大多数前列腺癌有可能发展为去势抵抗性。前列腺癌细胞由于激活促肿瘤信号通路以及对各种治疗方式产生耐药性，从而表现出对化疗、放疗、雄激素剥夺疗法（ADT）的耐药性以及免疫惰性。在此背景下，纳米药物如脂质体、纳米颗粒、分支树枝状大分子、碳纳米管和量子点是很有前景的疾病管理技术。纳米药物可以将药物靶向输送到目标部位，并长时间增强药物作用。它们还可能提高难溶性药物的溶解度和生物利用度。本综述总结了目前关于纳米药物预防和治疗前列腺癌的数据。因此，纳米医学在疾病管理方面正处于领先地位。
