Institute of Pharmaceutical Research, GLA University, Mathura, 281406, Uttar Pradesh, India.
Curr Pharm Biotechnol. 2023;24(3):366-390. doi: 10.2174/1389201023666220309154439.
Cancer has become one of the world's most lethal and life-threatening disorders, resulting in many deaths. Drug targeting and managing drug delivery are concepts that are implemented to increase a drug's therapeutic index by enhancing its specificity to particular cells, tissues, or organs and reducing its action and harmful side effects. Liposomes have proven to be one of the most innovative drug delivery systems in medicine. Immunoliposomes, also known as antibody-coupled liposomes, have gained a lot of attention as a homing device for targeted therapies. Monoclonal antibodies or antibody fragments that combine with liposomes to create immunoliposomes have been considered a leading technique for targeted delivery. Various functionalization strategies are adopted for the non-covalent and covalent binding of monoclonal antibodies and their components to liposomal surfaces, such as thiolation, amide bonds, hydrazone bonds, and electrostatic interactions, hydrophobic interactions, hydrogen bonding, etc. for cancer-specific targeting. This provides an overview of various stimulus-responsive immunoliposomes capable of regulating drug release in response to an exogenous magnetic field, changes in temperature or pH, enzyme concentration, endogenous stimuli, and applications of immunoliposomes in vaccination and cancer therapeutics and endogenous immune response stimulation.
癌症已成为世界上最致命和威胁生命的疾病之一，导致许多人死亡。药物靶向和管理药物输送是为了通过增强药物对特定细胞、组织或器官的特异性并减少其作用和有害副作用来提高药物治疗指数而实施的概念。脂质体已被证明是医学中最具创新性的药物输送系统之一。免疫脂质体，也称为抗体偶联脂质体，作为靶向治疗的归巢装置引起了广泛关注。与脂质体结合以形成免疫脂质体的单克隆抗体或抗体片段被认为是靶向递药的领先技术。各种功能化策略被用于非共价和共价结合单克隆抗体及其组件到脂质体表面，例如硫醇化、酰胺键、腙键和静电相互作用、疏水相互作用、氢键等，以实现癌症特异性靶向。本文概述了各种刺激响应免疫脂质体，这些脂质体能够响应外磁场、温度或 pH 值变化、酶浓度、内源性刺激以及免疫脂质体在疫苗和癌症治疗和内源性免疫反应刺激中的应用来调节药物释放。
