Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Curr Drug Saf. 2022;17(4):393-398. doi: 10.2174/1574886317666220309143913.
Pregabalin is used in the treatment of neuropathic pain of various etiologies and as an adjuvant in epilepsy. Blockade of the α2δ subunit of L and N-type Ca-channels is its main mechanism of neurotropic action. Compared to other antiepileptics like phenytoin, valproate and lamotrigine, and other neuropathic pain medications such as amitriptyline and duloxetine, pregabalin has a relatively favorable safety profile and hence is a drug of choice for many geriatricians.
Here we describe a case of maculopapular rash induced by pregabalin in an older man, which resolved with withdrawal of the offending drug and conservative management.
We have also conducted a literature review of similar cases and highlighted the clinical patterns and management strategies for pregabalin-induced skin rashes.
普瑞巴林用于治疗各种病因的神经病理性疼痛，并作为抗癫痫药物的辅助用药。阻滞 L 和 N 型钙通道的 α2δ 亚基是其主要的神经作用机制。与其他抗癫痫药如苯妥英、丙戊酸和拉莫三嗪，以及其他神经病理性疼痛药物如阿米替林和度洛西汀相比，普瑞巴林具有相对较好的安全性，因此是许多老年病医生的首选药物。
在此，我们描述了一位老年男性因普瑞巴林引起的斑丘疹病例，停用致疹药物并进行保守治疗后皮疹消退。
我们还对类似病例进行了文献复习，并强调了普瑞巴林引起皮疹的临床模式和管理策略。
