Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, China.
Department of Pain Management, Zhongnan Hospital of Wuhan University, Wuhan, China.
J Int Med Res. 2024 Apr;52(4):3000605241245004. doi: 10.1177/03000605241245004.
Pregabalin is the first-line treatment for neuropathic pain. Cases of cutaneous hypersensitivity reactions caused by pregabalin generally occur within 2 weeks of initiating medication. We report a rare case of a delayed cutaneous hypersensitivity reaction caused by pregabalin, which was confirmed by a drug provocation test. A 72-year-old man with severe herpes zoster neuralgia developed maculopapular drug eruption covering 80% to 90% of his total body surface area after 40 days of combined multidrug analgesia. A drug provocation test for pregabalin was positive. The time interval between initiating medication and the onset of the patient's rash was the longest and he also had the largest area of skin affected compared with patients with a similar condition in previous related reports. Remaining vigilant for possible adverse cutaneous hypersensitivity reactions during treatment is important because of the long-term course of pregabalin treatment for neuropathic pain.
普瑞巴林是治疗神经病理性疼痛的一线药物。普瑞巴林引起的皮肤过敏反应一般在开始用药后 2 周内发生。我们报告了一例罕见的由普瑞巴林引起的迟发性皮肤过敏反应病例，该病例通过药物激发试验得到证实。一名 72 岁男性，患有严重的带状疱疹神经痛，在联合使用多种药物镇痛 40 天后，全身 80%至 90%的皮肤出现斑丘疹性药物疹。普瑞巴林药物激发试验阳性。与之前类似病例报告中药物疹发作时间最长和受累皮肤面积最大的患者相比，该患者开始用药到皮疹发作的时间间隔最长。由于神经病理性疼痛的普瑞巴林治疗需要长期进行，因此在治疗过程中保持警惕，注意可能出现的不良皮肤过敏反应非常重要。
